Introduction The nerve fibers in central nervous system are surrounded by myelin sheet which is formed by oligodendrocytes. Cell therapy based on oligodendrocytes and their precursors transplantation can hold a promising alternative treatment for myelin sheet repair in demyelinating diseases. Methods Human Dental Pulp Stem Cells (hDPSCs) are noninvasive, autologous and easy available source w...

Pulpal disease, specifically dental pulpitis, is triggered by exogeneous stimuli from cariogenic bacteria or traumatic injury. The specific host defense in the dental pulp is regulated by the innate and adaptive immunity, of which the pulp-dentin complex odontoblasts play an essential role in the early stage of the dental immune response. It has been reported that the NLRP3 inflammasome is expr...

The incidence of COVID-19 as a global pandemic led many researchers from various fields to find solutions manage the spread and treat patients suffering disease. This discovery vaccines which greatly reduced COVID-19. However, stem cell therapy was also proposed be suitable option in treatment same, due its immunomodulatory properties. There are ongoing clinical trials with approaches for preve...