objective: in this study, we sought to better understand the immunoregulatory function of stem cells derived from human exfoliated deciduous teeth (shed). we studied the role of the interferon gamma (ifn-γ)-indoleamine 2,3-dioxygenase (ido)-axis in immunoregulation of shed compared to bone marrow derived mesenchymal stem cells (bmmscs) under the same conditions. materials and methods: in this c...

Introduction: Recognition of human leukocyte antigens (HLA) is of importance for hematopoietic stem cell transplantation. Any HLA-mismatches between the donor and recipient can cause graft rejection or other complications. In HLA-typing experiments, usage of HLA-known reference cells accompany with HLA-unknown samples is obligatory. Some international centers represent these cells with high e...

background: umbilical cord tissue is a very rich source of mesenchymal stem cells. instead of discarding this source we are banking the tissue along with cord blood for possible future cell based applications. the cord tissue needs to be transported and stored properly in order for it to be good enough for cell isolation at a later date. in this paper we have carried out a validation study to d...

introduction : use of adipose-derived stem cells (adscs) is a suggested hypothesis to enhance the regeneration of bone defects. this technique is of particular interest since adscs are more easily accessible via a non-invasive harvesting technique compared to bone marrow stem cells (bmscs). this study sought to assess the efficacy of adsc implantation for regeneration of localized mandibular bo...

ex vivo expansion of human umbilical cord blood cells (hucbc) is explored by several investigators to enhance the repopulating potential of hucbc. the proliferation and expansion of human hematopoietic stem cells (hsc) in ex vivo culture was examined with the goal of generating a suitable clinical protocol for expanding hsc for patient transplantation. using primary human mesenchymal stem cells...

background: the aim of this study was to investigate the percentage of the stem cells population in human endometrial tissue sections and cultured cells at fourth passage. methods: human endometrial specimens were divided into two parts, one part for morphological studies and the other part for in vitro culture. full thickness of human normal endometrial sections and cultured endometrial cells ...

mesenchymal stem cells (mscs) have the ability to differentiate into neuronal like cells under appropriate culture condition. in this study, we investigated whether mscs derived from human peripheral blood (pb-mscs) can differentiate into neuronal like cells by synergic effect of the growth factors egf, bfgf and noggin. for this purpose, the expression of five neuronal markers (nestin, β iii tu...

BACKGROUND Meningiomas are the most commonly diagnosed primary intracranial neoplasms. Despite significant advances in modern therapies, the management of malignant meningioma and skull base meningioma remains a challenge. Thus, the development of new treatment modalities is urgently needed for these difficult-to-treat meningiomas. The goal of this study was to investigate the potential of buil...