The discrimination between functionally neutral amino acid substitutions and non-neutral mutations, affecting protein function, is very important for our understanding of diseases. The rapidly growing amounts of experimental data enable the development of computational tools to facilitate the annotation of these substitutions. Here, we describe a Random Forests-based classifier, named Mutation ...

OBJECTIVE To compare results obtained with the NC-stat--an automated nerve testing device--to traditional nerve conduction studies relevant to carpal tunnel syndrome screening. METHODS Thirty-three subjects recruited from patients referred for electrodiagnostic testing were studied. Measurements including the distal motor latency (DML), distal sensory latency (DSL), and median-ulnar latency d...

Human cytomegalovirus (hCMV) reactivation may often coincide with the development of graft-versus-host-disease (GVHD) in stem cell transplantation (SCT). Seventy seven SCT donor-recipient pairs (DRP) (HLA matched unrelated donor (MUD), n = 50; matched related donor (MRD), n = 27) underwent whole exome sequencing to identify single nucleotide polymorphisms (SNPs) generating alloreactive peptide ...

in present investigation the biological leaching of aluminum by isolated fungi from red mud, the main waste product of the alkaline extraction of al from bauxite was studied. biological leaching experiments were carried out using indigenous, date and orange specimen fungi, aspergillus niger, penicillium simplicissimum notatum. savored dextrose chloramphenicol agar (sda) was used as medium for t...

BACKGROUND Very little is known regarding the persistence of Highly Pathogenic Avian Influenza (HPAI) H5N1 viruses in aquatic environments in tropical countries, although environmental materials have been suggested to play a role as reservoirs and sources of transmission for H5N1 viruses. METHODOLOGY/PRINCIPAL FINDINGS The survival of HPAI H5N1 viruses in experimental aquatic biotopes (water,...

Due to human activities huge amount of organic wastes are simply dumped in the environment creating disposal and pollution problems. Suitable and sustainable utilization of these wastes is vermicomposting which converts wastes in to wealth. In the present study, 1:1 proportion (wt./wt.) of vegetable market waste (VMW) and press mud (sugar industry waste) mixture have been used for vermicomposti...

Two distinct cDNAs encoding aquaporins (mmAQPs 1a and 3a) were isolated and characterized from mud loach Misgurnus mizolepis. The identified mud loach AQP cDNAs encode for polypeptides of 260 and 302 amino acids. Topology predictions confirmed six putative membrane-spanning domains connected by five loops and the Nand C-terminal domains being cytoplasmic. The mud loach AQPs 1a and 3a showed bro...

THE recent excavation of many ancient sites in Palestine enables us to form a fair, though necessarily an incomplete, conception of the hygienic conditions of ancient times. From the earliest housedwellers down to at least the "Greek" period, the streets and houses of even the most important towns of Palestine resembled those of its modern villages. The streets were very narrow and crooked, lai...

MUD (Multiple User Dungeon) systems are client-server. When the single server goes down, everyone is kicked off and no one can log on. Also, even if there are only a handful of people talking in a given room, a large overall number of users can slow the server and cause lag (higher latency) which makes fluent communication impossible. We introduce Happy Fun MUD, a distributed, peer-to-peer MUD ...