Morphological changes are a very common and effective strategy for pathogens to survive in the mammalian host. During interactions with their host, human pathogenic fungi undergo an array of morphological changes that are tightly associated with virulence. Candida albicans switches between yeast cells and hyphae during infection. Thermally dimorphic pathogens, such as Histoplasma capsulatum and...

U ndifferentiated human monocytes encounter various pathogens while present in the bloodstream. They are considered a primary responder and regulator for human immune reactions. As such, experiments investigating responses to pathogens are often reliant on monocyte cell cultures. For reproducibility reasons, immortalized cell lines are used. One of the most important cell lines used to model pa...