Recent technologic advancement enables us to prepare leukocyte-depleted or UVB-irradiated platelet concentrates for possible prevention of primary HLA alloimmunization. However, it is yet not known which of these two approaches is more efficacious. Because well-controlled studies cannot be easily conducted in human subjects to answer this question, a series of experiments were performed using a...

OBJECTIVE To study the relationship between human platelet alloantigens-2 (HPA-2) polymorphism, Kozak sequence polymorphism, macroglycopeptide region variable number of tandem repeats (VNTR) polymorphism of GPIbα and coronary heart disease (CHD). METHODS In the present study, blood obtained from 403 patients with CHD and 500 healthy controls was detected by PCR or PCR-RFLP methods to analyze ...

Sir, Platelets and neutrophil antigen systems play important roles in immune-mediated disorders, since the respective alloantibodies and autoantibodies mediate immune thrombocytopenia and granulocytopenia. Serologic typing for human platelet antigen (HPA) and neutrophil-antigen (NA) systems is well developed but good quality sera are available only in a few specialized laboratories while DNA ba...

Geriatric depression is often associated dysregulation of the hypothalamus-pituitary-adrenal (HPA) axis, and with poor responsiveness to antidepressants that work through inhibition of monoamine reuptake; accordingly, it has been suggested that MAO inhibitors may represent a therapeutic alternative in this group. In the current study, we evaluated expression of MAO subtypes in brain regions of ...

Several cell surface and cytoplasmic markers specific for the megakaryocyte-platelet lineage have been described. However, as yet, none of these has been shown to be expressed on cells earlier than the committed megakaryocyte progenitor, CFU-Meg. The present study was aimed at determining whether platelet lineage antigens could be detected on human pluripotential stem cells. Rabbit antiserum ag...

Neonatal alloimmune thrombocytopenia (NAITP) is the commonest cause of severe thrombocytopenia in neonates,' with intracerebral haemorrhage leading to neurologic damage in utero being a recognized complication.2 The condition is caused by maternal alloimmunization to antigenic epitopes of paternal origin in one of the biallelic human platelet antigen (HPA) systems, usually HPA-I, resulting in a...