This scientific report describes the effect of feeding detoxified karanj seed cake as protein replacement of soya bean meal on immunity and pathology in growing lambs. Twenty-four male lambs, 4-6 months of age were divided into four groups of six each and fed with different levels of detoxified karanj seed cake (dKC 0%, dKC 25%, dKC 50%, dKC 75%) for 140 days. Effect on humoral and cell mediate...

3 Monnier, M. and Hatt, A. M.: Intraventricular infusions in acute and chronic rabbits. Application of the stereotaxic method of Monnier and Gangloff. Pflügers Arch. ges. Physiol. 317: 268-277 (1970). 4 Monnier, M. and Hatt, A. M. : New evidence of humoral transmission of sleep. Experientia 27: 722 (1971). 5 Monnier, M. and Hatt, A. M.: Humoral transmission of sleep. V. New evidence from produc...

BACKGROUND Hepatitis D virus (HDV) DNA vaccine can produce Th1 and cytotoxic T-cell immune responses but only a low anti-HDV antibody titer is generated with a large hepatitis D antigen (L-HDAg) construct. In contrast, DNA vaccine expressing small hepatitis D antigen (S-HDAg) can generate a high titer of anti-HDV antibodies. Whether the low humoral immunity of L-HDAg DNA vaccine is due to inade...

yr HERE IS INCREASING EVIDENCE that the thymus has a central role in the development of the immune system.1’2 Surgical removal of the thymus in newborn mice and rats results in wasting, lymphocytopenia, and impaired immune responses.”2 Previous studies from our laboratory demonstrated that similar effects were also produced in hamsters subjected to neonatal thymectomy.3’4 The existence of a hum...

yr HERE IS INCREASING EVIDENCE that the thymus has a central role in the development of the immune system.1’2 Surgical removal of the thymus in newborn mice and rats results in wasting, lymphocytopenia, and impaired immune responses.”2 Previous studies from our laboratory demonstrated that similar effects were also produced in hamsters subjected to neonatal thymectomy.3’4 The existence of a hum...

3 Monnier, M. and Hatt, A. M.: Intraventricular infusions in acute and chronic rabbits. Application of the stereotaxic method of Monnier and Gangloff. Pflügers Arch. ges. Physiol. 317: 268-277 (1970). 4 Monnier, M. and Hatt, A. M. : New evidence of humoral transmission of sleep. Experientia 27: 722 (1971). 5 Monnier, M. and Hatt, A. M.: Humoral transmission of sleep. V. New evidence from produc...

Inclusion body myositis (IBM) belongs to a group of muscle diseases known as the inflammatory myopathies. The presence of antibody-secreting plasma cells in IBM muscle implicates the humoral immune response in this disease. However, whether the humoral immune response actively contributes to IBM pathology has not been established. We sought to investigate whether the humoral immune response in ...

OBJECTIVE To evaluate vaccine coverage and humoral immunity to tetanus, diphtheria and poliomyelitis in adults followed for systemic inflammatory and/or autoimmune diseases (SIADs). METHODS A cross-sectional study was conducted between June and August 2006 in a monocentric cohort of adults with SIAD. A standardized questionnaire was administered to collect medical, therapeutic and vaccine cov...

The development of a successful vaccine against HIV is likely to require the induction of strong and long-lasting humoral immune responses at the mucosal portal of virus entry. Hence, the design of a vaccine strategy able to induce mucosal antibodies and in particular specific IgA, may be crucial to providing immune protection. Nasal immunisation is known to induce specific IgG and IgA response...

Antibody responses to tumor antigens play an important role in initiating a cellular antitumor response with respect to antigen cross-presentation and T cell cross-priming. Successful vaccination strategies rely on an optimally timed activation of the humoral and cellular immune system by using appropriate adjuvant stimulation. The LUD99-008 trial used the cancer testis antigen NY-ESO-1 formula...