Huntington's disease (HD) is a neurological caused by trinucleotide repeat increase in the huntingtin (htt) gene, which widely expressed brain and peripheral tissues. While many studies have focused on cognitive, psychological, motor symptoms of HD, however, scope pathology its possible impact central has received less attention. We hypothesised that because disruption gastrointestinal microbio...

Huntington disease (HD) is a neurodegenerative disease that afflicts about 1 in 10,000 individuals. Symptoms include uncontrollable choreiform or dance-like movements, impairment in memory and reasoning ability, and alterations in personality. The average age of onset of symptoms is about 40 years. The symptoms become increasingly disabling with time, and patients die 15 to 20 years after the f...

BACKGROUND Several studies have suggested a greater risk of suicide in Huntington disease (HD); however, unique risk factors for suicide in HD are not established. OBJECTIVE We sought to determine risk factors for suicidal behavior, defined as suicide or attempted suicide, in prodromal HD. METHODS From the prospective PREDICT-HD cohort, we identified 735 cases with HD gene expansion but no ...

Although spouses play a major role in managing the care of persons affected with Huntington disease (HD), often at the price of subordinating their own aspirations and needs, little or no professional attention has been given to them in the HD literature. Such factors as secrets kept from the spouse, the early age-of-onset of symptoms, gender, and the coping strategies employed by spouses of af...