Naturally derived regulatory T cells (Tregs) may prevent graft-versus-host disease (GVHD) while preserving graft-versus-leukemia (GVL) activity. However, clinical application of naturally derived regulatory T cells has been severely hampered by their scarce availability and nonselectivity. To overcome these limitations, we took alternative approaches to generate Ag-specific induced Tregs (iTreg...

Experiments were carried out to test the validity of the hypothesis that postulated differences in the nature of the antigen receptors of primary and secondary B cells should be reflected in a greater specificity in primary B-cell stimulation (2). Enumeration of clonal precursors stimulated by either DNP-Hy, TNP-Hy, or a mixture of both antigens confirmed this hypothesis. Since the sum of prima...

High- and low-yawning rats (HY and LY) were selectively bred as a function of their spontaneous yawning frequency with the LY subline about 2 yawns/hr and the HY 20 yawns/hr. The HY rats have more grooming bouts and travel longer distances in an open field. HY dams spent less time in the nest, retrieved their pups faster, and show a longer latency to licking and mouthing the pups than the LY or...

We report the characterization in the human genome of 966 pseudogenes derived from the four human Y (hY) RNAs, components of the Ro/SS-A autoantigen. About 95% of the Y RNA pseudogenes are found in corresponding locations on the chimpanzee and human chromosomes. On the contrary, Y pseudogenes in mice are both infrequent and found in different genomic regions. In addition to this rodent/primate ...

The aim of this study was to investigate beak surface temperature changes stress induced by fear resulting from tonic immobility using infrared thermography in laying hens. It also examined whether temperatures differed among brown and white lines. based on 89 hens both lines: 45 White Leghorn birds 44 Hy-Line birds. Beak measured with immediately before after testing. average obtained the uppe...

We report on the spectroscopy of the 5s 1S0 (F = 9/2) → 5s5p 3P0 (F = 9/2) clock transition of Sr atoms (natural linewidth of 1 mHz) trapped in a one-dimensional optical lattice. Recoilless transitions with a linewidth of 0.7 kHz as well as the vibrational structure of the lattice potential were observed. By investigating the wavelength dependence of the carrier linewidth, we determined the mag...

In the title hydrate, C(10)H(10)O(4)·H(2)O, the six-membered aliphatic ring that is fused to the benzene ring has a sofa shape, with the hy-droxy group in the 3-position (that represents the sofa back) of the aliphatic ring occupying a quasi-axial position. The hy-droxy group of the aromatic ring is hydrogen-bond donor to the carbonyl O atom; other O-H⋯O hydrogen bonds link the organic mol-ecul...

Le sentiment de rejet et mépris, l’absence perspectives, la défiance à l’égard des institutions du pouvoir, paradoxalement combinée avec une demande d’autorité, conduisent aux quatre coins continent manifestations colère sociale. Ces colères s’enclenchent suite décisions politiques ou catastrophes évitables. On citera l’accident ferroviaire en Grèce, les restrictives conservateurs anglais, taxe...