background: with respect to the prevalence of leishmaniosis in our country and the problems occurred in the therapeutic approaches and also with respect to the previous successful reports of paromomycin efficacy in this regard, the present study was conducted to determine the effects of paromomycin and gentamicine sulphate on promastigotes of leishmania major.materials and methods: it was an ex...

Commercial tablets of Rosuvastatin Calcium exhibit unsatisfactory dissolution profiles and, consequently, problems of absorption and poor bioavailability. Rosuvastatin Calcium (RST), a poorly water-soluble 3-hydroxy3-methyl glut aryl CoA (HMG-CoA) Reductase inhibitor through inclusion complexation with hydroxy propyl β-cyclodextrin (HP-β-CD). The aim of this work was to develop Rosuvastatin Oro...

Ionotropic gelation method was used to entrap Ketoprofen (KP) into calcium alginate beads. KP is one of the non steroidal anti-inflammatory drugs (NSAIDs); it has a short half life (1.5-2 h) and deleterious side effects on GIT such as irritation and ulceration. Beads were investigated in-vitro for possible sustained drug release and in-vivo as a gastro-protective system for KP. The curing time ...

The closely related title compounds, 3-(2,5-dimeth-oxy-3,4,6-tri-methyl-phen-yl)propyl methacrylate, C18H26O4 (I), and 3-(2,4,5-trimethyl-3,6-dioxo-cyclo-hexa-1,4-dien-yl)propyl methacrylate, C16H20O4 (II), are monomers suitable for the preparation of redox polymers. They consist of a propyl-methacrylate group and three methyl substituents on di-meth-oxy-benzene and quinone cores, respectively....

A specific role for the dopamine D3 receptor in behavior has yet to be elucidated. We now report that dopamine D2/D3 agonists elicit dose-dependent yawning behavior in rats, resulting in an inverted U-shaped dose-response curve. A series of experiments was directed toward the hypothesis that the induction of yawning is a D3 receptor-mediated effect, whereas the inhibition of the yawning observe...

Text mining (TM) applications in the field of biomedicine are gaining great interest. TM tools can facilitate formulation development by analyzing textual information from patent databases, scientific articles, summary products characteristics, etc. The aim this study was to utilize perform qualitative analysis paracetamol (PAR) and ibuprofen (IBU) formulations, terms identifying evaluating pre...

Photoluminiscent (PL) cellulose aerogels of variable shape containing homogeneously dispersed and surface-immobilized alloyed (ZnS)x(CuInS2)1-x/ZnS (core/shell) quantum dots (QD) have been obtained by (1) dissolution of hardwood prehydrolysis kraft pulp in the ionic liquid 1-hexyl-3-methyl-1H-imidazolium chloride, (2) addition of a homogenous dispersion of quantum dots in the same solvent, (3) ...

The formation of the important flavor compound 4-hydroxy-2,5-dimethyl-3[2H]-furanone (HDMF; Furaneol) from D-fructose-1,6-bisphosphate by the yeast Zygosaccharomyces rouxii was studied with regard to the identification of intermediates present in the culture medium. Addition of o-phenylenediamine, a trapping reagent for alpha-dicarbonyls, to the culture medium and subsequent analysis by high-pr...

reaction between aromatic aldehydes and 3–methyl-1-phenyl-2-pyrazoline-5-one catalyzed by nano-sio2/hclo4 in water under reflux provided a simple and efficient route for the synthesis of 4-((5-hydroxy-3-methyl-1-phenyl-1h-pyrazol-4-yl)(aryl)methyl)-3-methyl-1-phenyl-1h-pyrazol-5-ol derivatives in high yields.