Introduction: Recently, an indirect MRI detection of hydroxyl protons of small metabolites via the water signal was reported [1]. Selective off-resonance irradiation attenuates the water signal via chemical exchange saturation transfer (CEST) between hydroxyl and water protons. It was found that the magnetisation transfer (MT) asymmetry ratio (MTRasym) depends nonlinearly on hydroxyl-group conc...

A vast majority of the studies addressing the free radicals including hydroxyl radical is a damage compound of biochemical molecules such as DNA, proteins and lipids. When free radicals specially hydroxyl radical are not adequately removed from the body, it may damage biological macromolecules, leading to a variety of disease occurs. Therefore, the body should be protected by an enzymatic or no...

Sir: In 1967, UMEZAWA et al.1) found a kanamycin-neomycin phosphotransferase in Escherichia coli carrying R factor and proved that the resistance is directly related to the formation of this enzyme.2) In 1972, YAGISAWA et al.3) found another phosphotransferase in E. coli carrying a different R factor. These enzymes were different in their substrate specificities. The former which is now called ...

Menadione (MD; 2-methyl-1,4-naphthoquinone), a redox cycling quinone was shown to induce single (ss)- and double (ds)-strand DNA breaks in human MCF-7 cells. This DNA damage was mediated via the hydroxyl radical as evidenced by electron spin resonance spectroscopy (ESR) studies utilizing the spin trap, 5,5-dimethyl-1-pyrroline-1-oxide. The free radical production and DNA damage were shown to pl...

Electron paramagnetic resonance spectroscopy is used to observe hydroxyl radicals produced by an atmospheric pressure nonthermal plasma device at distances greater than 1 m from the discharge. The plasma device is an indirect treatment setup with closed loop airflow and hydrogen peroxide additives that is effective in deactivating bacteria on time scales of seconds. The generation of the detect...

The effect of transferrins on hydroxyl radical formation from the superoxide anion and hydrogen peroxide generated by the xanthine-xanthine oxidase system has been studied by EPR using 5,5-dimethyl-1-pyrroline N-oxide as a spin trap. Neither diferriclactoferrin nor diferrictransferrin were found capable of promoting hydroxyl radical formation via the Haber-Weiss reaction even in the presence of...

The title mefloquine derivative has been crystallized as its 1:1 methanol solvate, C(19)H(18)F(6)N(2)O(2)·CH(3)OH. Each of the meth-ine-hydroxyl residue [the C-C-C-O torsion angle is -16.35 (17) °] and the piperidinyl group [distorted chair conformation] lies to one side of the quinolinyl ring system. The hydroxyl and carbonyl groups lie to either side of the mol-ecule, enabling their participa...

Creation of high-density localized spins in the basal plane of graphene sheet by introduction of sp(3)-type defects is considered to be a potential route for the realization of high-magnetization graphene. Theoretical and experimental studies confirmed that hydroxyl can be an effective sp(3)-type candidate for inducing robust magnetic moment. However, the artificial generation of hydroxyl group...

Supramolecular integration of a saddle-distorted zinc(II) porphyrin complex, which has hydroxyl groups at the para-position of the four meso-aryl groups, has been demonstrated on the basis of hydrogen bonding among the peripheral hydroxyl groups. The hydrogen-bonding patterns were controlled by the recrystallization solvents and additives, and particularly, addition of a bifunctional ligand suc...