AIMS Hyoscine (scopolamine), which is effective in the prophylaxis of motion sickness, shows similar binding affinities to all of the five known muscarinic receptor sub-types. The effectiveness of hyoscine was compared with zamifenacin (UK-76654), which binds selectively to the muscarinic M3 and m5 receptors. METHODS Eighteen subjects received hyoscine hydrobromide 0.6 mg, zamifenacin 20 mg, ...

In this work, we report about the mechanical relaxation characteristics of an intrinsically self-healable imidazole modified commercial rubber. This kind of self-healing rubber was prepared by melt mixing of 1-butyl imidazole with bromo-butyl rubber (bromine modified isoprene-isobutylene copolymer, BIIR). By this melt mixing process, the reactive allylic bromine of bromo-butyl rubber was conver...

Lorazepam 2 and 4 mg alone and in combination with atropine 0.4 mg and hyoscine 0.4 mg were studied as i.v. surgical premedicants in 150 patients. Relief of anxiety, sedation, patient acceptance, lack of recall and side-effects were evaluated. Hyoscine was found to improve the relief of anxiety and sedation associated with lorazepam, but did not significantly increase lack of recall or patient ...

A standard operative procedure and anaesthetic technique were employed to compare the effects of 0.6 mg atropine and 0.4 mg hyoscine, given as part or all of premedication, on the course of thiopentone anaesthesia. The incidence and severity of muscle movement following induction was increased by the use of hyoscine, but not to the same extent as previously found with methohexitone. This effect...

Electron transfer collisions between beams of neutral K atoms and neutral alkyl bromide ~R–Br! molecules (R5CH3 ,t-C4H9) are observed by detecting positive and negative ions in coincidence for energies *4 eV, the minimum energy for overcoming the Coulomb attraction between ions. The molecules are state selected by a hexapole electric field and oriented prior to the electron transfer. The steric...

Purpose: Prolong labour contributes to increased perinatal and maternal morbidity. Inhibitory impulses in the form of spasm often impair the dilatation of cervix and prolong the duration of labour. This study was undertaken to compare the effect of intramuscular Valathemate bromide [Epidosin] and Hyoscine N Butylbromide [Buscopan] rectal suppository on duration of labour and rate of cervical di...

In the title benzamide derivative, C(11)H(14)ClNO, the chloro-benzene and butyl-amine groups are each planar, with mean deviations from the planes of 0.013 and 0.030 Å, respectively, and a dihedral angle of 2.54 (9)° between the two planes. In the crystal structure, N-H⋯O hydrogen bonds link mol-ecules in rows along a. Short inter-molecular Cl⋯Cl inter-actions [3.4225 (5) Å] link these rows int...