background: asthma is a chronic inflammatory disorder of the airways. the available treatment options have major limitations owing to low efficacy, associated adverse events and compliance issues. therefore, the health burden of bronchial asthma is increasing globally at an alarming rate, providing a strong impetus for the development of new therapeutics. myrica sapida is known traditionally in...

Profound acidemia impairs cellular and organ function and consequently should be associated with an increased risk of mortality in critically ill humans and animals. Neonatal diarrhea in calves can result in potentially serious metabolic derangements including profound acidemia due to strong ion (metabolic) acidosis, hyper-D-lactatemia, hyper-L-lactatemia, azotemia, hypoglycemia, hyperkalemia a...

In budding yeast, loss of topoisomerase III, encoded by the TOP3 gene, leads to a genomic instability phenotype that includes slow growth, hyper-sensitivity to genotoxic agents, mitotic hyper-recombination, increased chromosome missegregation, and meiotic failure. Slow growth and other defects of top3 mutants are suppressed by mutation of SGS1, which encodes the only RecQ helicase in S. cerevis...

The generalized singular value decomposition (GSVD) is a valuable tool that has many applications in computational science. However, computing the GSVD for large-scale problems challenging. Motivated by hyper-differential sensitivity analysis (HDSA), we propose new randomized algorithms which use subspace iteration and weighted QR factorization. Detailed error given provides insight into accura...

Bipolar-valued fuzzification of the notion of implicative hyper BCK-ideals is considered. Using the concepts of positive and negative lever sets, a characterization of a bipolar fuzzy implicative hyper BCK-ideal is provided. A relation between a bipolar fuzzy hyper BCK-ideal and a bipolar fuzzy implicative hyper BCK-ideal is established. A condition for a bipolar fuzzy hyper BCK-ideal to be a b...

In this paper we introduce the concepts of hyper P -semisimple Ialgebra and Abelian hyper I-algebra and we state and prove some related results. The hyper p-semi simple I-algebras is a generalization of p-semisimple BCI-algebras and a subclass of hyper I-algebras. Specially we show that every Abelian hyper I-algebra is a hyper psemisimple I-algebra and a commutative canonical hypergroup. In fol...

Abstract The next generation long-baseline neutrino oscillation experiment, Hyper-Kamiokande, will consist of a 260 kt underground water Cherenkov detector, placed 295 km from the source at J-PARC. This is generated by 1.3 MW proton beam striking target. In addition, suite near detectors, both on and off-axis be used. With this, Hyper-Kamiokande aims to perform precision measurements parameters...

We present a simple explicit construction of hyper-Kähler and hyper-symplectic (also known as neutral hyper-Kähler or hyper-parakähler) metrics in 4D using the Bianchi type groups of class A. The construction underlies a correspondence between hyper-Kähler and hyper-symplectic structures in dimension four.