نتایج جستجو برای: hyperoxia
تعداد نتایج: 3247 فیلتر نتایج به سال:
Hyperoxia causes cell injury and death associated with reactive oxygen species formation and inflammatory responses. Recent studies show that hyperoxia-induced cell death involves apoptosis, necrosis, or mixed phenotypes depending on cell type, although the underlying mechanisms remain unclear. Using murine lung endothelial cells, we found that hyperoxia caused cell death by apoptosis involving...
Breathing high levels of oxygen (i.e. hyperoxia) causes hyperventilation and unstable breathing in normal and carotid-deafferented animals (1,2). Prolonged exposure to hyperoxia can disrupt central nervous system (CNS) function and result in a condition termed CNS O2 toxicity, the primary sign of which is convulsion (3,4). The mechanism by which hyperoxia stimulates ventilation and disrupts CNS...
RATIONALE Oxygen supplementation (e.g., hyperoxia) is used to support critically ill patients with noninfectious and infectious acute lung injury (ALI); however, hyperoxia exposure can potentially further contribute to and/or perpetuate preexisting ALI. Thus, developing novel therapeutic agents to minimize the side effects of hyperoxia is essential to improve the health of patients with severe ...
BACKGROUND Hyperoxia-induced hypercapnia in subjects with COPD is mainly explained by alterations in the ventilation/perfusion ratio. However, it is unclear why respiratory drive does not prevent CO2 retention. Some authors have highlighted the importance of respiratory drive in CO2 increases during hyperoxia. The aim of the study was to examine the effects of hyperoxia on respiratory drive in ...
INTRODUCTION The safety of arterial hyperoxia is under increasing scrutiny. We performed a systematic review of the literature to determine whether any association exists between arterial hyperoxia and mortality in critically ill patient subsets. METHODS Medline, Thomson Reuters Web of Science and Scopus databases were searched from inception to June 2014. Observational or interventional stud...
The aim of the present study was to observe the expression of sonic hedgehog (Shh) and Ptc signaling molecules in the lungs of newborn rats exposed to prolonged hyperoxia, and to explore the role of the SHH signaling pathway in hyperoxia‑induced lung injury. Newborn Sprague-Dawley rat pups were placed in chambers containing room air or oxygen above 95% for 14 days following birth. The rats were...
Hypozincemia, with hepatic zinc accumulation at the expense of other organs, occurs in infection, inflammation, and aseptic lung injury. Mechanisms underlying zinc partitioning or its impact on extrahepatic organs are unclear. Here we show that the major zinc-binding protein, metallothionein (MT), is critical for zinc transmigration from lung to liver during hyperoxia and preservation of intrap...
Purpose: To investigate the effect of rhubarb on hyperoxia-induced lung injury in neonatal rats with bronchopulmonary dysplasia (BPD), and underlying mechanism.Methods: Sixty 4-day-old were assigned to air control, BPD, intervention groups, 20 each group. Immunoblotting was employed assay NF-κB expression. Levels malondialdehyde (MDA) SOD determined spectrophotometrically, while ELISA used meas...
PURPOSE OF REVIEW Currently, no neuroprotective therapies have been shown to reduce the secondary neuronal damage occurring after traumatic brain injury. Recent studies have addressed the potentiality of hyperoxia to ameliorate brain metabolism after traumatic brain injury. In this article, we present the principles of oxygen transport to the brain, the effects of hyperoxia on cerebral metaboli...
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