Dapsone is chemically sulfonamide with its leprostatic mechanism used in the treatment of Hansen’s disease. It one safest drugs leprosy patients. Apart from safety, it associated various adverse effects such as hemolytic anemia, allergic dermatitis, agranulocytosis, methaemoglobinemia, and dapsone hypersensitivity syndrome (DHS). DHS typically presents fever, skin eruptions, Jaundice, hepatomeg...

Phenytoin hypersensitivity syndrome (PHS) is a rare delayed hypersensitivity reaction which occurs following exposure to phenytoin sodium. Pulmonary involvement is uncommonly described. Herein is reported the first case of histopathologic bronchiolitis obliterans organizing pneumonia (BOOP) found on open-lung biopsy in a patient with severe PHS. New onset, clinically significant, cold agglutini...

lamotrigine-associated anticonvulsant hypersensitivity syndrome [in French]. Rev Neurol (Paris) 2009;165:821-7. 3. Nagai Y, Hattori T, IshikawaO. A case of hypersensitivity syndrome due to phenytoin. J Dermatol 2002;29:670-3. 4. Molg oM, Carre~ noN, Hoyos-Bachiloglu R, AndresenM,Gonz alez S. Use of intravenous immunoglobulin for the treatment of toxic epidermal necrolysis and Stevens-Johnson/to...

Fanconi anemia (AF) is a hereditary genetic disease characterized by developmental abnormalities, progressive bone marrow failure, hypersensitivity to alkylating agents, and tendency hematological solid tumors throughout life. The only curative option in the treatment of failure patients with AF allogeneic hematopoietic stem cell transplantation (allo-HSCT). There are no detailed descriptions a...