The expectation that hyperthermia would be effective in the treatment of cancer is attributable to a theoretical viewpoint based upon biological studies. Cancer cells, which characteristically are hypoxic with poor nutrition and low pH, are sensitive to temperatures over 42.5 degrees C. This is the theoretical basis which assures the effectiveness of hyperthermia when used in combination with r...

A fever patient has disease and at the same time. From this, there is no system of separate from its symptoms, signs, signals, actions. Method distinguishing hyperthermia, fever, disease. Hyperthermia can be divided into two types. Destructive hyperthermia. Protective The immune produces partial or total heat in body to increase blood flow patients with reduced due inflammation. This not part I...

In tissue culture, the cytotoxicity of a number of commonly used chemotherapeutic drugs is greatly enhanced at elevated temperatures. However, pharmacokinetics, drug concentra tions, oxygen tension, and pH in tumors in animals can all vary widely from those in cell cultures. In addition, tissue culture studies do not give vital information on the effect of combina tions of drugs and hyperthermi...

External microwave (EMW) hyperthermia system (2.45 GHz wave frequency) was evaluated by in vitro studies and in vivo pleural metastasis animal model. Three different non-small-cell lung cancer cells and normal fibroblast cells (control) were treated once a day for 3 days with the prototype EMW system applying mild (39 degrees C), moderate (43 degrees C), and severe (47 degrees C) hyperthermia. ...

Epithelial ovarian cancer (EOC) is the leading cause of gynecological cancer death in the United States. Cisplatin is a DNA damaging agent initially effective against EOC but limited by resistance. P53 plays a critical role in cellular response to DNA damage and has been implicated in EOC response to platinum chemotherapy. In this study, we examined the role of p53 status in EOC response to a n...

Hyperthermia (targeted core temperature: 38.5°C) reduces the time between gastrocnemius medialis stimulation and onset of plantar flexor force production in vivo. This reduction electromechanical delay is concomitant to an earlier motion muscle fascicle compared with thermoneutral environment. However, hyperthermia has no impact on duration transmission along aponeurosis tendon, thereby reflect...

background: tumor response after multimodality treatment using combination of radiation, chemotherapeutic drugs and hyperthermia usually assessed by parameters such as tumor growth delay, volume doubling time and regression response. the study herein was conducted to investigate the usefulness of micronucleus assay for assessing the multimodality treatment. materials and methods: the induction ...

In regional hyperthermia extensive numerical simulations are required for optimizing individual cancer therapy treatments. To take full advantage of such simulations a therapy planning system is needed. In this paper we discuss a new hyperthermia planning system, focussing on its visualization and 3D-interaction functionality. Our software, called HyperPlan, assists the whole treatment planning...

Hyperthermia is an experimental/adjuvant therapeutic modality for cancer. Combining hyperthermia with the non-invasive metabolic studies using magnetic resonance (MR) is an interesting area of research and can provide useful information. In this paper, feasibility of using the same radio frequency source for carrying out combined hyperthermia and MR studies is demonstrated. A conventional RF hy...

The effect of sequencing of the total course of hyperthermia and irradiation on local tumor control was studied on a murine tumor system (RIF). The results showed a 20% control rate for the treatment arms: (a) total course of irradiation followed by total course of hyperthermia; or (b) total course of hyperthermia followed by total course of irradiation. A superior (70%) control rate was achiev...