Hypertrophic scar is a complication of wound healing and has a high recurrence rate which can lead to significant abnormity in aesthetics and functions. To date, no ideal treatment method has been established. Meanwhile, the underlying mechanism of hypertrophic scarring has not been clearly defined. Although a large amount of scientific research has been reported on the use of medicinal plants ...

BACKGROUND Despite widespread beliefs regarding the use of topical tocotrienol in the prevention of hypertrophic scars, there is very little evidence from well controlled and randomised clinical trials to justify its benefits for surgical scars. OBJECTIVE This study was conducted to evaluate the efficacy of topical tocotrienol in preventing the development of hypertrophic scars. METHODS A p...

CONCLUSIONS: For the first time, our results reveal a decrease of the stemness marker CD34 in murine skin cells in hypertrophic scars over time compared to unwounded skin. We are currently conducting single cell transcriptional analyses and functional studies on these fibroblasts to understand the heterogeneity of fibroblasts during hypertrophic scarring and the specific role of CD34+ fibroblas...

CONCLUSIONS: For the first time, our results reveal a decrease of the stemness marker CD34 in murine skin cells in hypertrophic scars over time compared to unwounded skin. We are currently conducting single cell transcriptional analyses and functional studies on these fibroblasts to understand the heterogeneity of fibroblasts during hypertrophic scarring and the specific role of CD34+ fibroblas...

Keloids and hypertrophic scars represent an exuberant healing response that poses a challenge for physicians. Patients at high risk of keloids are usually younger than 30 years and have darker skin. Sternal skin, shoulders and upper arms, earlobes, and cheeks are most susceptible to developing keloids and hypertrophic scars. High-risk trauma includes burns, ear piercing, and any factor that pro...

Abnormal scarring and its accompanying esthetic, functional, and psychological sequelae still pose significant challe nges. To date, there is no satisfactory prevention or treatment option for hypertrophic scars (HSs), which is mostly due to not completely comprehending the mechanisms underlying their formation. That is why the apprehension of regular and controlled physiological processes of s...

BACKGROUND: The therapeutic arsenal for the treatment of hypertrophic scars and keloids has expanded significantly in recent years. Traditional methods treatment, such as intraocular injection corticosteroids, pressure therapy cryotherapy, are increasingly supplemented with new methods. level evidence approaches increased due to development systematic reviews national international recommendati...

Hypertrophic scars and keloids resulting from surgery, burns, trauma and infection can be associated with substantial physical and psychological distress. Various non-invasive and invasive options are currently available for the prevention and treatment of these scars. Recently, an international multidisciplinary group of 24 experts on scar management (dermatologists; plastic and reconstructive...

JOURNAL OF WOUND CARE JANUARY, VOL 9, NO 1, 2000 Most wound healing is well controlled, but over-abundant deposition of collagen may result in hypertrophic or keloid scarring.1 These scars are raised, hard, lumpy and erythematous, and pruritis is invariably a distressing symptom.2 The prime clinical feature distinguishing keloid from hypertrophic scarring is that keloid scar tissue progressivel...