Abnormal blood cell production is associated with chronic kidney disease (CKD) and cardiovascular disease (CVD). Bone-derived FGF-23 (fibroblast growth factor-23) regulates phosphate homeostasis and bone mineralization. Genetic deletion of Fgf-23 in mice (Fgf-23(-/-)) results in hypervitaminosis D, abnormal mineral metabolism, and reduced lymphatic organ size. Elevated FGF-23 levels are linked ...

The cause or causes of hypercalcemia and hypercalcuria in sarcoidosis are obscure. Harrell and Fisher (1) were the first to emphasize that hypercalcemia, hyperproteinemia and elevated serum alkaline phosphatase could occur in this disease. Dent etat (2) believed that bone destruction represented the cause of hypercalcemia. Anderson et at (3) concluded from their studies that increased calcium a...

Modern aquaculture feeds tend to contain lower levels of fish based ingredients, while increasing the content plant ingredients. However, this may alter vitamin profile feeds, leading unbalanced supply. Requirements for several vitamins have been established species such as carps and salmonids, but adequate gilthead sea bream are yet unknown. Vitamin D is mainly involved in Ca homeostasis by re...

Obesity is a global epidemic affecting populations globally. Bariatric surgery is an effective treatment for morbid obesity, and has increased dramatically. Bariatric surgery candidates frequently have pre-existing nutritional deficiencies that might exacerbate post-surgery. To provide better health care management pre- and post-bariatric surgery, it is imperative to establish the nutritional s...

Original Article 1. Introduction The incidence of chronic hypervitaminosis A is becoming more frequent problem worldwide due to the to the increasing use of vitamin A supplements in children of developing countries where vitamin A deficiency is commonplace, treatment of skin disorders such as acne and the increased number of people taking excessive doses of vitamin A for supposed beneficial hea...

Caffey disease or Infantile Cortical Hyperostosis (ICH) is a rare and mostly self limiting condition affecting young infants. It is characterized by acute inflammation of the periostium and the overlying soft tissue and is accompanied by systemic changes of irritability and fever. Diagnosis may be delayed as this disorder mimics a wide range of diseases including osteomyelitis, hypervitaminosis...

In this investigation the effects of excess vitamin A administration during the early embryonic period were studied. Intramuscular injection of a single dose of 15000,20000 or 25000 IU/kg vitamin A to pregnant Balb/c strain mice on either day 7,8,9 or 10 of gestation (vaginal plug= day 0 of gestation) produced major malformations in the central nervous system (CNS) including exencephaly, h...

Mice lacking the renal epithelial Ca(2+) channel TRPV5 (TRPV5(-/-)) display impaired renal Ca(2+) reabsorption, hypercalciuria, and intestinal Ca(2+) hyperabsorption, due to secondary hypervitaminosis D. Using these mice, we previously demonstrated that ZK191784 acts as an intestine-specific 1,25(OH)(2) D(3) antagonist without affecting serum calcium levels. On the other hand, it acted as an ag...