Endodontic emergencies are associated with pain and swelling which requires immediate diagnosis and treatment. The main causative factors for these emergencies are pulp and peri-radicular pathosis, traumatic injuries, procedural complications; were sodium hypochlorite accidents can occur. The impetus behind a successful root canal treatment relies on a thorough debridement of tissue remnants, b...

OBJECTIVE The purpose of this study was to analyze the consequences of HDL oxidation for paraoxonase-1 metabolism and function. METHODS AND RESULTS HDL was oxidized with AAPH, copper ions, and hypochlorite. Secretion studies were performed using human paraoxonase-1-transfected cells lines and primary rat hepatocytes. Stability studies were performed with recombinant paraoxonase. Conditioned m...

Chlorite dismutases (Clds) are heme b-containing prokaryotic oxidoreductases that catalyze the reduction of chlorite to chloride with the concomitant release of molecular oxygen. Over time, they are irreversibly inactivated. To elucidate the mechanism of inactivation and investigate the role of the postulated intermediate hypochlorite, the pentameric chlorite dismutase of "Candidatus Nitrospira...

STATEMENT OF PROBLEM The main purpose of a root canal treatment is to eliminate the bacteria and their products from the pulp space. Sodium hypochlorite has excellent antibacterial properties, but also some negative features. PURPOSE The aim of the present study is to compare the antimicrobial effect of Aloe Vera solution with sodium hypochlorite on E.faecalis in the root canals of human extr...

AIM To determine the antimicrobial effect of water extracts of leaves of Annona muricata and Simarouba glauca on Enterococcus faecalis using agar diffusion method. MATERIALS AND METHODS Dried leaves of A. muricata and S. glauca were powdered and extracted in a soxhlet apparatus. Enterococcus faecalis was grown overnight in Trypticase soy agar plates. About 10 μl of each extract was placed on ...

Purpose: To evaluate the efficacy of 0.5 % Sodium hypochlorite and 2% Glutaraldehyde spray disinfectants on impression compound and irreversible hydrocolloid impressions. Material and Methods: Twenty edentulous patients (age group of 45-65 years) were randomly selected for the present study. Maxillary and mandibular impressions of 10 patients were made in compound and remaining 10 patients in a...

Aims: To measure the microhardness of root canal dentin using two types of irrigating solutions( 0.2% Chlorhexidine and 5.25% Sodium Hypochlorite) with and with out use of different types of root canal files (Stainless Steel-K files, Nickel-Titanium K-files or rotary Nickel-Titanium files). Materials & methods: The teeth divided in to four groups according to the type of irrigating solutions th...

The objective was to compare the role of needles design (open ended versus closed ended) on the apical extrusion of sodium hypochlorite irrigant during root canal treatment. This was an in vitro study performed at the Department of Operative Dentistry, Liaquat University of Medical & Health Sciences, Jamshoro from March 2011 to October 2011. Access cavities were prepared in one hundred extracte...

Hypochlorite (HOCl) is one of the most important mediators inflammatory processes. Recent evidence demonstrates that changes in intracellular calcium pool play a significant role damaging effects hypochlorite and other oxidants. Mitochondria are shown to be targets hypochlorite. But little known about mitochondrial HOCl-induced dysfunction. Using isolated rat liver mitochondria, we showed oxida...