We report a case of Evans syndrome associated with scleroderma in a 50-year-old woman admitted to the department of internal medicine of Yalgado Ouedraogo National Teaching Hospital in Burkina Faso. The interest of this case lies in on its mode of revelation: chronic bleeding that led to hypochromic microcytic anemia. The indirect antiglobulin test was positive. Corticosteroid treatment has bee...

Fever of unknown origin (FUO) can be an unusual first clinical manifestation of pheochromocytoma. Pheochromocytomas are tumors that may produce a variety of substances in addition to catecholamines. To date, several cases of IL-6-producing pheochromocytomas have been reported. This report describes a 45-year-old woman with pheochromocytoma who was admitted with FUO, normal blood pressure levels...

By ERNEST BEUTLER AND DIANA HOFSTRA R ECENTLY, Holl#{225}n’ described a most interesting phenomenon : profound anemia in rats following unilateral section of the sciatic and femoral nerves. The hematologic features of this anemia were described in some detail. It was hypochromic, and the reticulocyte count was increased. There was erythroblastic hyperplasia of the marrow. Fecal urobilin excreti...

Methods: A cross-sectional study was done on patients with chronic, untreated, severe anemia with hemoglobin (Hb) less than 8g% and a hypochromic microcytic peripheral smear. Blood indices, reticulocyte count, iron studies and bone marrow examination were done.All patients were treated either with oral or parenteral iron and the outcome was evaluated a day before discharge and 28 days post-trea...

Moderate anaemia of a hypochromic, normocytic type is a common feature of rheumatoid arthritis (Friereich, Ross, Bayles, Emerson, and Finch, 1957). Macrocytic anaemia has been reported less frequently. Macrocytosis was regarded as co-incidental by Short, Bauer, and Reynolds (1957) or due to anticonvulsant drugs (Chanarin, Laidlaw, Loughridge, and Mollin, 1960). In a study of the bone marrow in ...

We present two Japanese students with thalassemia identified during screening for anemia in their junior high school. Blood test results revealed marked hypochromic and microcytic erythrocytosis in one patient and microcytic anemia in the other. Both cases showed a mean corpuscular volume/red blood cell (MCV/RBC) ratio less than 13. Their beta/alpha synthesis ratio was elevated. Deletion of psi...

The iron regulatory hormone hepcidin is transcriptionally up-regulated in response to iron loading, but the mechanisms by which iron levels are sensed are not well understood. Large-scale genetic screens in the zebrafish have resulted in the identification of hypochromic anemia mutants with a range of mutations affecting conserved pathways in iron metabolism and heme synthesis. We hypothesized ...

Eighteen cases of disseminated lupus erythematosus were verified by postmortem study in a series of 19,242 autopsies. Shortness of breath was the most common complaint and occurred in 16. Fourteen of this number had definite cardiac pathology. All 16 had definite pulmonary pathology. Fourteen cases had abnormal urinalysis. Of these cases, 7 had elevated blood nonprotein nitrogen values of over ...

Genetic causes of hypochromic microcytic anemia include thalassemias and some rare inherited diseases such as DMT1 deficiency. Here, we show that iron deficiency anemia with poor intestinal absorption and defective iron utilization of IV iron is caused by inherited mutations in TMPRSS6, a liver-expressed gene that encodes a membrane-bound serine protease of previously unknown role that was rece...