The diagnosis of Lyme disease may be a challenge in patients with Chronic Lymphocytic Leukemia. In relying on detection of antibodies in the serum for diagnosis we are presented with a problem in our patients with CLL in whom there is hypogammaglobulinemia secondary to B-cell malfunction. We suggest the use of PCR in aiding in diagnosis of Lyme disease in patients with CLL.

DOI: 10.5581/1516-8484.20110105 Academia de Ciência e Tecnologia – AC & T, São José do Rio Preto, SP, Brazil Flavio Augusto Naoum Warts, Hypogammaglobulinemia, Infections and Myelokathexis (WHIM) syndrome is a very rare form of severe congenital neutropenia with approximately only 40 cases reported until now. The name of this syndrome, WHIM, describes its main features that include, but are not...

Variable Common Immune Deficiency (VCID) is a very heterogeneous condition both clinically and immunologically. It group of molecular abnormalities responsible for defect in antibody production leading to hypogammaglobulinemia often associated with autoimmune and/or lymphoproliferative manifestations. Late Onset Combined (LOCID) type defined by (IgG IgA ± IgM type), profound CD4 T-cell lymphope...

Background and Objectives. We evaluated bacterial infections (BIs) in patients with multiple myeloma (MM) treated with two different schedules of vincristine-adriamycin-dexamethasone (VAD). Design and Methods. Ninety-seven patients were studied during 340 VAD cycles. VAD was given by either continuous intravenous infusion (CII) to hospitalized patients or rapid intravenous infusion (RII) to out...