The present study investigates the relationship between the high-order structure and hypolipidemic activity of four well-defined sulfated fucans from sea cucumber. The chain conformation, determined by a combination of AFM and SEC-MALLS-RI, indicate that fucosylated chondroitin sulfate (fCS) from Pearsonothuria graeffei (fCS-Pg) and Isostichopus badionotus (fCS-Ib), and fucoidan from P.graeffei...

The present study investigated the insulin sensitivity, hypoglycemic, and hypolipidemic activities of ethanolic extract of Mirabilis jalapa L. root (EEM) in normal and diabetic mice. After induction of diabetes with streptozotocin, both normal and diabetic mice were singly or repeatedly for 28 days administrated with EEM at doses of 2, 4, 8 g/kg, respectively. Before induction of diabetes, mice...

In this study, the effect of mushroom extracellular polysaccharides on fatty acid composition and liver peroxisome proliferator-activated receptor-alpha (PPAR-α) expression in obese-diabetic rats was investigated, and distinguished the association among anti-obesity, hypoglycemic and hypolipidemic properties. Extracellular polysaccharides from three different strains of Pleurotus tuber-regium w...

The hypolipidemic effect of an exo-biopolymer produced from a submerged mycelial culture of Hericium erinaceus was investigated in dietary-induced hyperlipidemic rats. Hypolipidemic effects were proportionally increased with the increasing concentration of the exo-biopolymer for oral administration. The exo-biopolymer, at the dose of 200 mg/kg body weight, substantially reduced the plasma total...

The present study investigates the hypolipidemic effect of aqueous extract of whole plant of Melothria maderaspatana (AEMM) in high fat diet fed rats. In this study three doses (0.5, 1 and 2 gm kg) of AEMM were used. Treatment with AEMM (2 gm kg, p.o.) had shown significant reduction in the lipid level in high fat diet fed animals. The AEMM exhibited significantly hypolipidemic activity compara...

Isoflavones have been suggested to have hypolipidemic effects. As these compounds undergo complex metabolism in the body, the biological actions of isoflavone metabolites are largely unknown. We studied the hypolipidemic effects of two isoflavone metabolites initially identified in the human urine, cis-tetrahydrodaidzein (NV-04) and transtetrahydrodaidzein (NV-05) in apolipoprotein(E)-deficient...

Hyperlipidemia and many other metabolic diseases are related to oxidative stress. Centella asiatica is a traditional Chinese medicine whose antioxidant effect in vitro has been reported. We are interested in whether it possesses this effect in vivo and hence modulates lipid metabolism. Therefore, experiments were carried out on mice and golden hamsters regarding its antioxidant and hypolipidemi...