5 p P ackground & Aims: Evidence suggests that postpranial platelet-depleted plasma 5-hydroxytryptamine (5T) concentrations may be abnormal in irritable bowel yndrome (IBS). However, interpretation of the data has een hampered by the variable methodology and rather mall numbers used in previous studies. Therefore, the im of this study was to measure concentrations of latelet-depleted plasma 5-H...

INTRODUCTION Irritable bowel syndrome (IBS) is a functional gastrointestinal (GI) disorder characterized by symptoms, such as abdominal pain, bloating, diarrhea, and constipation, that are not attributable to structural or biochemical abnormalities (1). Although several conceptual models of IBS pathogenesis have been suggested, including visceral hypersensitivity, abnormal intestinal motility, ...

Omalizumab is a humanized monoclonal antibody that binds to the high-affinity type-I IgE Fc receptors on mast cells (MCs) and basophils, inhibiting the IgE immune pathway. Irritable bowel syndrome (IBS) is the most common functional gastrointestinal disorder, and dysregulation of the immune system likely contributes to its etiology and/or symptomatology. Colonic biopsies from patients with IBS ...

• Objective: To determine the incidence and treatment cost of oral candidiasis among patients using triamcinolone acetonide (TAA) as their only inhaled bronchial steroid (IBS) and patients using other IBS agents. • Design: A retrospective analysis was conducted using a pharmacy benefits management claims database. • Patients: Patients between 6 and 80 years of age were included in the study if ...

Traditionally, irritable bowel syndrome (IBS) has not been regarded as an organic disease, and the pathophysiology of IBS is heterogeneous. Currently, the diagnosis of IBS is based upon the Rome diagnostic criteria. The performance of these criteria is only modest in predicting IBS, and moreover their validation is lacking. Additionally, as functional symptoms are common in the general populati...

When specifically asked, about one third of people report recurrent upper abdominal discomfort, and irritable bowel syndrome (IBS) and chronic gastritis (CG) maybe the most frequently diagnosed ones among all. Consecutive patients with upper abdominal discomfort applying to the Internal Medicine Polyclinic were included into the study. IBS was diagnosed according to Rome II criteria and CG was ...

OBJECTIVE To investigate the frequency of irritable bowel syndrome (IBS) and health seeking behaviour in patients belonging to different ethnic groups and their squatter settlements in two cities of Pakistan. METHODS Questionnaire based on Rome II criteria for the diagnosis of IBS was sent to 1167 persons living in, Karachi and Bahawalpur and their squatter settlements in Baloch Colony and Ti...

BACKGROUND Irritable bowel syndrome (IBS) is assumed as one of the most frequent gastrointestinal disorders, which decreases the patient's quality of life. IBS pathogenesis, however, is not clearly defined. It seems that sleep apnea induces or escalates IBS clinical symptoms. This study aims at evaluating of IBS prevalence in patients, who are afflicted or are not afflicted with sleep apnea. ...

Several studies have reported an association between GNβ3 C825T polymorphism and irritable bowel syndrome (IBS). However, the results remain inconclusive and controversial, particularly for the data derived from different ethnicities and IBS subtypes. Therefore, we performed an updated meta-analysis to evaluate this association. All eligible case-control studies that met the search criteria wer...

BACKGROUND Many patients with irritable bowel syndrome (IBS) have lowered sensory thresholds to rectal distention when compared to control subjects, a phenomenon called visceral hypersensitivity. AIM To investigate the usefulness of a rectal barostat as a diagnostic tool in IBS and if there are differences in visceral hypersensitivity in different groups of IBS patients. PATIENTS AND METHOD...