Intracranial atherosclerotic disease (ICAD) is the most common proximate mechanism of ischemic stroke worldwide. Approximately half of those affected are Asians. For diagnosis of ICAD, intra-arterial angiography is the gold standard to identify extent of stenosis. However, noninvasive techniques including transcranial ultrasound and MRA are now emerging as reliable modalities to exclude moderat...

Apoptotic changes of the nucleus induced by Fas (Apo1/CD95) stimulation are completely blocked by reducing intracellular ATP level. In this study, we examined the ATP-dependent step(s) of Fas-mediated apoptotic signal transduction using two cell lines. In SKW6.4 (type I) cells characterized by rapid formation of the death-inducing signaling complex on Fas treatment, the activation of caspases 8...

Pinin (Pnn), a serine/arginine-rich (SR)-related protein, has been shown to play multiple roles within eukaryotic cells including cell-cell adhesion, cell migration, regulation of gene transcription, mRNA export and alternative splicing. In this study, an attempt to generate mice homozygously deficient in Pnn failed because of early embryonic lethality. To evaluate the effects of loss of Pnn ex...

BACKGROUND Cervical artery dissection (CeAD) patients with or without stroke are frequently treated with either antiplatelet agents or vitamin K antagonists (VKAs), but few data are reported on the use of nonvitamin K oral anticoagulants (NOACs). METHODS Between November 2011 and January 2014, we recorded data from patients with a stroke due to vertebral (VAD) or internal carotid artery disse...

Sonification as a complement of visualization is been under research for decades new ways data deployment. ICAD conferences, gather together specialists from different disciplines to discuss about sonification. Different tools sonoUno, starSound and Web Sandbox are attempt reach tool open astronomical sets sonify it in conjunction visualization. In this contribution, the sonoUno web version pre...

One score and 4 years after the first PTA for treatment of intracranial atherostenosis I did the first in man WINGSPAN-procedure for intracranial atherosclerotic disease (ICAD). This was the beginning of an encouraging trial known as WINGSPAN trial (HDE-Trial). Target patients had symptomatic ICAD and had failed antithrombotic therapy. Technical success rate was 100% and the 30-day composite ip...