A new syndrome has been described comprising polyneuropathy, oedema, hyperpigmentation and thickening of the skin, gynaecomastia in males and amenorrhoea in females, monoclonal gammopathy, papilloedema and diabetes. There is frequent osteosclerosis with or without plasmacytoma, hepatosplenomegaly and polycythaemia. There is a good response to corticosteroids, immunosuppressive drugs and occasio...

Osteoarthritis (OA) most frequently involves the hands, knees, hips, and spine; it is diagnosed on the basis of joint pain and radiographic evidence of non-uniform narrowing of a joint space, osteophytes, and subchondral osteosclerosis and cysts [1,2]. There are three etiological classifications; Type I is genetic, Type II is estrogen-dependent, and Type III is aging-related [3] (Table 1). The ...

In the article on the isolated bone marrow mastocytosis (IBMM) as an underestimated subvariant of indolent systemic mastocytosis (ISM), Zanotti et al. reported that 54.7% of patients with unexplained/recurrent anaphylaxis or severe allergic reactions were found to be suffering from IBMM. They conclude that the incidence of IBMM can be frequently underestimated, especially in the face of a lack ...

Skeletal radiographs of 122 patients treated by maintenance haemodialysis were reviewed retrospectively for bone disease. Significant radiological bone changes were very low at commencement of dialysis (29%), as well as at six months of dialysis (6.1%). This figure rose to 19.7% when the total period of dialysis was considered. In the latter group, fractures occurred in seven patients (5.7%), e...

Erdheim-Chester disease (ECD) is a rare form of systemic histiocytosis, typically presenting with striking osseous involvement characterized by bilateral osteosclerosis and involvement of organs such as the lung, pituitary gland, heart, and brain. Liver involvement with ECD is extremely uncommon. We report a 56-year-old woman presenting with newly diagnosed cirrhosis and signs concerning for in...

1Department of Oral and Maxillofacial Radiology, School of Dentistry and Dental Research Center, Mashhad University of Medical Sciences, Mashhad, Iran 2Department of Oral and Maxillofacial Radiology, School of Dentistry and Dental Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran 3Clinical Research Development Center, Rafsanjan University of Medical Sciences, Rafsanjan,...

osteoporosis provided that the food is eligible for the claim and the claim is consistent with the current regulations. The prospective claim relating to the relationship between calcium and bone disease, specifically, increased bone density and the risk of fractures, is not consistent with the existing claim, and would misbrand any food on which it is used. Because firms can highlight the rela...