نتایج جستجو برای: idiopathic pulmonary fibrosis
تعداد نتایج: 345058 فیلتر نتایج به سال:
Interstitial pneumonias have recently been associated with mutations in the gene encoding surfactant protein C (SFTPC). In particular, SFTPC mutations have been reported in a number of familial forms of pulmonary fibrosis and in infants with interstitial lung diseases. The present study searched for SFTPC mutations in adult patients with sporadic idiopathic interstitial pneumonia. In total, 35 ...
Introduction: Idiopathic pulmonary fibrosis (IPF) is a relentlessly progressive and usually fatal lung disease of unknown etiology for which no effective treatments currently exist. In the adults type I and II pneumocytes, forms Components of the alveolar epithelial cells. In this study, we investigated the effect of thalidomide on the alveolar epithelial cells (type I and II pneumocytes) in ...
idiopathic pulmonary fibrosis (ipf) is a chronic lung disease of unknown etiology. recent investigations have demonstrated that the impaired immune response is a common characteristic feature of ipf. unfortunately, no definitive and effective drug treatment is available that could improve or at least inhibit the progressive course of this fatal disease. that is why one of the main priorities of...
BACKGROUND Despite intense research efforts, the aetiology and pathogenesis of idiopathic pulmonary fibrosis remain poorly understood. Gelsolin, an actin-binding protein that modulates cytoskeletal dynamics, was recently highlighted as a likely disease modifier through comparative expression profiling and target prioritisation. METHODS To decipher the possible role of gelsolin in pulmonary in...
In 1980, the question “Is there a fibrotic gene?” was posed in an editorial [1] commenting on a report about pulmonary fibrosis in monozygotic twins. Over the next 37 years, the identification of kindreds of families with pulmonary fibrosis and advances in DNA sequencing provided answers to this question. An early example of a gene associated with pulmonary fibrosis involved a case of familial ...
conclusions results of the present study showed that hydroalcoholic extracts of pomegranate seeds had a significant protective effect against bleomycin-induced lung fibrosis by its antioxidant properties. the highest protective effect was observed for the 400 mg/kg dose. results histological analysis showed that pse could prevent pathological changes that were seen in the bleomycin group. objec...
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Does interferon-c improve pulmonary function in idiopathic pulmonary fibrosis? A. Prasse, K-M.Müller, C. Kurz, H. Hamm, J.C. Virchow Jr. #ERS Journals Ltd 2003. ABSTRACT: Idiopathic pulmonary fibrosis (IPF) is a disease with progressive and devastating deterioration of lung function and a fatal prognosis, despite aggressive therapeutic attempts, which, in the majority of cases are futile. Recen...
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