How high doses of intravenous IgG (IVIG) suppress autoimmune diseases remains unresolved. We have recently shown that the antiinflammatory activity of IVIG can be attributed to a minor species of IgGs that is modified with terminal sialic acids on their Fc-linked glycans. Here we propose that these Fc-sialylated IgGs engage a unique receptor on macrophages that, in turn, leads to the upregulati...

mRNAs are transported, localized, and translated in axons of sensory neurons. However, little is known about the full repertoire of transcripts present in embryonic and adult sensory axons and how this pool of mRNAs dynamically changes during development. Here, we used a compartmentalized chamber to isolate mRNA from pure embryonic and adult sensory axons devoid of non-neuronal or cell body con...

Immunoglobulin G (IgG) is the main serum glycoprotein responsible for detection and destruction of pathogens or their noxious products. IgG consists of Fab (‘fragment antigen binding’) regions, that recognize antigenic targets and provide diversity to antibodies, and Fc (‘fragment crystallizable’) regions, that allow antibodies to interact with Fc gamma receptors (FcgR) on phagocytes (Fig. 1). ...

CD25 is expressed at high levels on regulatory T (Treg) cells and was initially proposed as a target for cancer immunotherapy. However, anti-CD25 antibodies have displayed limited activity against established tumors. We demonstrated that CD25 expression is largely restricted to tumor-infiltrating Treg cells in mice and humans. While existing anti-CD25 antibodies were observed to deplete Treg ce...

The dissemination of the dengue virus (DENV) in endemic regions with HIV is a public health concern greater importance when there evidence vertical transmission DENV during pregnancy. Herein, we investigated among HIV-infected pregnant women Luanda, capital city Angola. This was part cross-sectional study carried out on 42 newly diagnosed HIV. A total 36 plasma samples from HIV-positive were sc...

Human IgG is a well-established multifunctional antigen specific immunoglobulin molecule of the adaptive immune system. However, an antigen nonspecific immunological function of human IgG has never been reported. In this study, human IgG was isolated using ammonium sulfate fractional precipitation and diethylaminoethanol (DEAE) cellulose 52 ion exchange chromatography, from which h-IgG and hs-I...

Background Immunosuppressive medication reduces the immunogenicity of coronavirus disease 2019 (COVID-19) vaccines in patients with rheumatic and musculoskeletal diseases (RMDs). However, underlying mechanism remains unclear. The primary aim our study was to dissect impact immunosuppressive on cellular humoral immune responses RMD receiving inactivated COVID-19 vaccine. Methods A total 28 five ...

Objective To review the clinical/oncological presentations of gamma aminobutyric acid-B receptor (GABABR)-IgG and evaluate clinical specificity antibody testing methodologies. Background GABABR-IgG is an intermediate-risk paraneoplastic autoantibody commonly associated with encephalitis and/or seizures. Design/Methods positive patients tested at Mayo Clinic Neuroimmunology Laboratory were ident...

Treatment of covalently cross-linked or heat-aggregated oligomers of human IgG with 4 mMtetranitromethane abrogated their Clq-binding activity. In contrast, tetranitromethane modification of rabbit IgG oligomers, under identical conditions, had no effect upon their Clq-binding activity. The tetranitromethane treatment led to nitration of about ten tyrosine residues per IgG molecule in both spec...