Thirty eight patients with subacute sclerosing panencephalitis (SSPE) were investigated. Five patients who previously had measles immunoglobulin M (IgM) detected in unfractionated serum and cerebrospinal fluid (CSF) had measles IgM exclusively in the low molecular weight (LMW) fractions of serum and CSF. Measles IgM had previously not been found in unfractionated serum from 33 patients but was ...

A spontaneous lymphoma (141) producing monoclonal IgM is established in NZB/NZW F(1) (B/W) mice who spontaneously develop an autoimmune disease. Idiotypic determinants of 141 IgM are present on the lymphoma cell surface as shown by indirect immunofluorescence and specific cytotoxicity with rabbit anti-idiotypic antiserum. Fluorescence and cytotoxicity are inhibited by 141 IgM but not by 104E Ig...

OBJECTIVES Anti-pneumococcal capsular polysaccharide (PCP) IgM, IgG and IgA ELISAs have been developed to aid assessment of the adaptive immune system. The relationship between the concentrations of PCP IgM, IgG, and IgA was investigated. DESIGN AND METHODS The concentrations of PCP IgM, IgG, and IgA were measured in sera obtained from 231 adult blood donors. RESULTS Concentrations of each ...

Primary and secondary antibody responses in blood of teleost fish are mainly IgM mediated, as they lack an IgG homolog and a class switch mechanism. Thus, the major serum immunoglobulin is tetrameric IgM. A unique antibody class in teleosts; named IgT, appears to be specialized for mucosal immunity and is present in low concentrations in serum. A third class; IgD was recently detected in serum ...

BACKGROUND Hepatitis delta frequently leads to liver cirrhosis and hepatic decompensation. As treatment options are limited, there is a need for biomarkers to determine disease activity and to predict the risk of disease progression. We hypothesized that anti-HDV IgM could represent such a marker. METHODS Samples of 120 HDV-infected patients recruited in an international multicenter treatment...

Abstract We use the measured scattering timescales of fast radio bursts (FRBs) from CHIME catalog to derive an upper limit on magnetic field subkiloparsec scales in intergalactic medium (IGM). A nonmagnetized, photoionized IGM is insufficient explain turbulent at all redshifts, with a warm-hot component being marginally consistent data z ∼ 1. Accounting for lower envelope temporal smearing dist...

The warm-hot intergalactic medium (warm-hot IGM, or WHIM) pervades the filaments of Cosmic Web and harbours half Universe's baryons. WHIM's thermodynamic properties are notoriously hard to measure. Here we estimate a galaxy group - WHIM boundary temperature using new method. In particular, use radio image giant (giant RG, GRG) created by NGC 6185, massive nearby spiral. We analyse this extraord...

IgG class antibodies against human IgM were detected in a human subject up to a titer of 1:1024 against 5 of a group of 23 monoclonal Waldenström macroglobulins. Inhibition studies confirmed at least one antigenic determinant shared by the 5 IgMs. The determinant was present on the mu chain but required tertiary structure for its full expression. Inhibition of the reaction between the antibodie...

AIM To determine the role of immunoglobulin M (IgM) deposits in clinical manifestations, disease outcome, and treatment response of idiopathic and secondary focal segmental glomerulosclerosis (FSGS). METHODS Kidney biopsy specimens of 171 patients diagnosed with FSGS (primary and secondary) and 50 control patients were retrospectively included in the study. For each patient, clinical and outc...