Febrile convulsion (FC) is the most common type of seizure in childhood that occurs in 2-5 % of the children younger than 6 years. Interleukin 1β (IL-1β) is a cytokine that contributes to febrile inflammatory responses. There are conflicting results on increasing this cytokine in serum during FC. Thus we measured IL-1ß in febrile children with or without seizure. 60 febrile children (6 months t...

Brain death (BD) has been associated with an immunological priming of donor organs and is thought to exacerbate ischemia reperfusion injury (IRI). Recently, we showed that the essential nitric oxide synthase co-factor tetrahydrobiopterin (BH4) abrogates IRI following experimental pancreas transplantation. We therefore studied the effects of BD in a murine model of syngeneic pancreas transplanta...

Genetic and molecular studies have confirmed the central role of amyloid-ß production and fibrillation in the pathogenesis of Alzheimer’s disease (AD). However, the pathological pathways from amyloid-ß peptide oligomerization to the major pathological hallmarks of AD, such as neurofibrillary tangles, inflammation and loss of cholinergic neurons, are largely unknown. The innate immunity defence ...

Yesterday’s ESC Hot Line: Late Breaking Clinical Trials I Session marked a historic turning point in cardiology with a host of seminal, practice-changing data being presented. One of the highlights was the landmark CANTOS study that showed reducing inflammation, even in the absence of lipid lowering, significantly reduces recurrent cardiovascular events. Canakinumab, a drug currently indicated ...

Introduction: Cataract is the main cause of visual impairment and vision loss in world, where 33% world's population has decreased due to cataracts. This study aims explore role platelet-rich plasma (PRP) inhibiting pro-inflammatory cytokine interleukin-1ß, thereby triggering tissue repair cataract cases vivo study.
 Methods: an experimental with a post-test-only approach control group des...

Cytokines are small proteins with a molecular mass lower than 30 kDa. They are produced and secreted on demand, have a short life span and only travel over short distances if not released into the blood circulation. In addition to the classical interleukins and the chemotactic chemokines, growth factors like VEGF or FGF and the colony stimulating factors are also considered cytokines since they...

OBJECTIVE In this study, anti-inflammatory effects of Royal Jelly were investigated by inducing renal inflammation in rats with the use of ethylene glycol. For this purpose, the calcium oxalate urolithiasis model was obtained by feeding rats with ethylene glycol in drinking water. MATERIALS AND METHODS The rats were divided in five study groups. The 1st group was determined as the control gro...

Thromboxane A2 receptor (TXA2R) activation is thought to be involved in thrombosis/hemostasis and inflammation responses. We have previously shown that TXA2R antagonist SQ29548 attenuates BV2 microglia activation by suppression of ERK pathway, but its effect is not tested in vivo. The present study aims to explore the role of TXA2R on microglia/macrophages activation after ischemia/reperfusion ...

kappaB (NF-κB) family of proteins (RelA, RelB, c-Rel, p50 and p52) and DNA are vital for cells to function normally; for example, in the human myometrium, NFκB-regulated pro-inflammatory mediators, including TNFα, IL-1ß, IL-8 and COX-2 are associated with the onset of labour. NF-κB, however, regulates the expression of over 400 genes, although it is unlikely these would all be activated in conc...