Abstract Background Emerging evidence suggests that epithelial cell-derived microRNAs (miRNA) are involved in the pathogenesis of inflammatory bowel disease; however, as now specific implications real clinical practice, especially relation to biologics use yet far-fetched. Therefore, we tried investigate cell derived miRNA signatures related and endoscopic activity Crohn’s disease (CD) patients...

A 69-year-old Caucasian male presented with a 6-month history of watery diarrhea without bleeding or weight loss. The patient had received chemotherapy for lung cancer 2 years before the appearance of his symptoms. His laboratory tests revealed eosinophilia, with an absolute eosinophil count of 1950 cells/μL in peripheral blood, without other inflammatory markers. Stool culture was negative for...

To cite: Tominaga K, Kato M, Takahashi K, et al. BMJ Case Rep Published online: [please include Day Month Year] doi:10.1136/ bcr-2013-203229 DESCRIPTION A youth in his later teenage years was referred to our hospital with erythema nodosum in his lower extremities. He had previously received surgical treatment for an anal fistula at another hospital. The patient presented with weight loss and fe...

AIM To investigate the correlation between rs2910164, rs11 614913, rs113054794, and rs188519172 polymorphisms and response to anti-TNF treatment in patients with Crohn's disease (CD). METHODS One hundred seven patients with CD based on standard clinical, endoscopic, radiological, and pathological criteria were included in the study. They all received infliximab or adalimumab intravenously or ...

INTRODUCTION Objective assessment of Crohn's disease (CD) activity in patients treated with anti-tumour necrosis factor (anti-TNF) antibodies is crucial for the prediction of its long-term results. Mucosal healing estimated endoscopically has a strong predictive value; however, only combined assessment together with transmural healing in magnetic resonance enterography (MRE) gives full informat...

BACKGROUND/AIMS Peyer's patches (PPs) are aggregates of lymphoid follicles that are mainly located in the distal ileum; they play a major role in mucosal immunity. We recently reported that patients with ulcerative colitis (UC) have alterations in PPs that can be detected using narrow-band imaging with magnifying endoscopy (NBI-ME). However, the usefulness of NBI-ME in UC treatment as a whole i...

BACKGROUND & AIMS Few prospective data are available to support the clinical relevance of mucosal healing in patients with Crohn's disease. This study examined whether complete healing, determined by endoscopy, predicts a better outcome in Crohn's disease. METHODS One-hundred thirty-three newly diagnosed and treatment-naïve Crohn's disease patients were given either a combination of immunosup...

Abstract Background Intestinal ultrasound (IUS) is a non-invasive monitoring tool increasingly being used to assess response therapy in Crohn’s disease (CD). Herein we describe the longitudinal evolution of IUS parameters, and its correlation with clinical, laboratorial endoscopic parameters during first year infliximab (IFX) therapy. Methods Prospective multicentre cohort study patients active...

Abstract Background Diagnostics of small bowel Crohn’s disease (CD) may be difficult. Combined PET-MRI has been documented to a reliable tool for evaluating intestinal metabolism, but clinical use limited due accessibility, costs and lack standardized methods quantify inflammation. Our study aims prove that combined can used detect active CD inflammation in bowel. Methods 25 patients with suspe...

Abstract Background Endoscopic post-operative recurrence (ePOR) is common following ileocecal resection (ICR) in patients with Crohn’s disease (CD), reaching up to, 70% at, 1-year. In clinical trials, prophylaxis anti-TNF therapies demonstrated a decrease ePOR to around, 20% Here we aimed compare the effectiveness of vedolizumab (VDZ) and ustekinumab (UST) anti-TNFs for preventing after curativ...