Minute difference in free energy change of unfolding among structures in an oligonucleotide sequence can lead to a complex population equilibrium, which is rather challenging for ensemble techniques to decipher. Herein, we introduce a new method, molecular population dynamics (MPD), to describe the intricate equilibrium among non-B deoxyribonucleic acid (DNA) structures. Using mechanical unfold...

Targeted monoclonal antibody therapy is an important strategy in cancer therapeutics. Among the most promising characteristics of therapeutic targets are those that modulate the growth and survival of malignant neoplasms and their sensitivity to anticancer therapies. The insulin-like growth factor-I receptor (IGF-IR) is overexpressed in many types of solid and hematopoietic malignancies, and ha...

Markov chains are widely used to determine system performance and reliability characteristics. The vast majority of applications considers continuous-time Markov chains (CTMCs). This note motivates how concurrency theory can be extended (as opposed to twisted) to CTMCs. We provide the core motivation for the algebraic setup of Interactive Markov Chains. Therefore, this note should have better b...

PURPOSE Vascular endothelial growth factor receptor-1 (VEGFR-1) plays important roles in promotion of tumor growth by mediating cellular functions in tumor vascular endothelium and cancer cells. Blockade of VEGFR-1 activation has been shown to inhibit pathologic angiogenesis and tumor growth, implicating VEGFR-1 as a potential therapeutic target for the treatment of cancer. We have thus develop...

Introducción: La leptina, hormona secretada en el tejido adiposo, altera la señalización de la dopamina en el núcleo accumbens, lo que afecta directamente la sensibilidad a la recompensa y la modulación de la abstinencia. Objetivo: Evaluar el nivel de leptina en suero y su relación con el estado nutricional entre los abstemios y los alcohólicos activos. Métodos: Se incluyeron en el estudio paci...

The novel contactless current sensors consist of an integrated CMOS Hall effect sensor covered by a thin, ferromagnetic layer structured on its surface. The Integrated Magnetic Concentrator (IMC) layer acts as a magnetic flux concentrator, providing a high magnetic gain which increases the sensor’s signal-to-noise ratio. The sensor is particularly appropriate for DC and AC current measurement. ...

Effects of the 2003 European heatwave on the Central Mediterranean Sea surface layer: a numerical simulation A. Olita, R. Sorgente, A. Ribotti, S. Natale, and S. Gabers̆ek IMC – International Marine Centre Loc. Sa Mardini, 09170 Oristano – Italy now at: University of Ljubljana, Department of Mathematics and Physics, Jadranska 19, Ljubljana, 1000-SI, Slovenia Received: 24 March 2006 – Accepted: 2...

This paper presents an Internal Model Control (IMC) structure designed for a class of continuous linear underactuated systems. The study treats the case of Minimum Phase (MP) systems and those whose zero dynamics are not necessarily stable. The proposed IMC structure is based on a specific controller which is obtained by the realization of an approximate inverse of the model plant. It is shown ...