BACKGROUND Most recent genome-wide studies on the CpG island methylation in colorectal cancer (CRC) have led to the discovery of at least 3 distinct methylation clusters. However, there remains an uncertainty whether the CRC clusters identified in these studies represent compatible phenotypes. METHODS We carried out comprehensive genome-scale DNA methylation profiling by Illumina Infinium Hum...

Bioactive agents (catalase - an enzyme, and nisin - a bacteriocin) were covalently immobilized on alginate activated with sodium periodate (oxidatively converting 2,3-dihydroxy groups into dialdehyde residues), followed or preceded by ionotropic gelation. For the same protein coupling yield, the retained enzyme activity of the immobilized enzyme (ImE) can be markedly increased by diminishing th...

In many eukaryotes, spliceosomal introns are able to influence the level and site of gene expression. The mechanism of this Intron Mediated Enhancement (IME) has not yet been elucidated, but regulation of gene expression is likely to occur at several steps during and after transcription. Different introns have different intrinsic enhancing properties, but the determinants of these differences r...

OBJECTIVES To assess the utility of an extratympanic intrameatal electrode for intraoperative monitoring during acoustic neuroma and other cerebellopontine angle tumour surgery and to define the neurophysiological and surgical factors which influence hearing preservation. METHODS Twenty two patients, 18 with acoustic neuromas and four with other cerebellopontine angle tumours, underwent intra...

In this paper, we design a continuous, t ime-varying tracking controller for an underactuated surface vessel in the presence of uncertainty associated with the hydrodynamic damping coefficients. A Lyapunov-based approach is used to ensure that the posi t ion/orientat ion tracking error is ultimately confined to a ball that can be made arbitrarily small. The result is achieved via the judicious ...

To analyze the complexity of decision problems on graphs, one normally assumes that the input size is polynomial in the number of vertices. Galperin and Wigderson 13] and, later, Papadimitriou and Yannakakis 18] investigated the complexity of these problems when the input graph is represented by a polylogarithmically succinct circuit. They showed that, under such a representation, certain trivi...

For high dimensional data, the redundant attributes of samplers will not only increase the complexity of the calculation, but also affect the accuracy of final result. The existing attribute reduction methods are encountering bottleneck problem of timeliness and spatiality. In order to looking for a relatively coarse attributes granularity of problem solving, this paper proposes an efficient at...

U ovom radu pomoću Sturm-Liouvilleova problema i određenih uvjeta dolazimo do Greenove funkcije koja je bitna u primjenjenoj matematici fizici. Ime dobila po britanskom matematičaru fizičaru Georgeu Greenu (1793. - 1841.). Koristi se mehanici, teoriji elektromagnetizma (Laplaceova jednadžba), kvantnoj fizici mnogim drugim područjima.

Our second project [14] showed how levels of abstraction, one of the most impor tant tools of discrete system analysis, can be used to reason about a simple acceleration maneuver. In this case, the goal is for a vehicle to reach a specified velocity vy at a specified t ime t I in the future. We assumed that the vehicle s tar ts at t ime 0 with velocity 0. The vehicle reports its velocity to the...