Abstract Immortality is a fundamental hallmark of human cancer cells and therapeutic reversal great interest. Telomerase Reverse Transcriptase promoter (TERTp) mutations reactivate TERT expression, the rate limiting step in telomerase activity cellular immortality. TERTp are most common non-coding mutation across all types, including glioblastoma (GBM), oligodendroglioma, medulloblastoma, high-...