The physiologic function of the immune system is defense against infectious microbes and internal tumour cells, Therefore, need to have precise modulatory mechanisms to maintain the body homeostasis. The mammalian cellular CD200 (OX2)/CD200R interaction is one of such modulatory mechanisms in which myeloid and lymphoid cells are regulated. CD200 and CD200R molecules are membrane proteins that t...

Hair loss is a common adverse event of long-term epidermal growth factor receptor (EGFR)-inhibitor anti-cancer treatment. This severe cutaneous side effect often leads to dose reduction or cessation the otherwise successful targeted therapy. Additionally, hair an important part one’s identity, and losing it can lead social isolation low quality life. Mouse models follicle-specific deletion EGFR...

Functional and effective immune response requires a metabolic rewiring of immune cells to meet their energetic and anabolic demands. Beyond this, the availability of extracellular and intracellular metabolites may serve as metabolic signals interconnecting with cellular signaling events to influence cellular fate and immunological function. As such, tumor microenvironment represents a dramatic ...