Infection of CFW mice with Trichinella spiralis induced a state of relative unresponsiveness to passive cutaneous anaphylaxis (PCA) induced with hen egg albumin and its corresponding antibodies. The unresponsiveness was to PCA produced either with immunoglobulin G, (IgG,) or IgE type of antibodies, but was more pronounced with the latter. As few as 25 larvae given by stomach tube 20 days before...

BACKGROUND Immunoglobulin E (IgE) has traditionally been associated with anaphylaxis and atopic disease. Previous studies reported that serum IgE levels are elevated in nephrotic syndrome and suggested IgE levels as a prognostic indicator in glomerular diseases. The aim of this study was to explore the association between serum IgE levels and renal outcome in patients with immunoglobulin A neph...

Immunoglobulin E and its interactions with receptors FcϵRI and CD23 play a central role in allergic disease. Omalizumab, a clinically approved therapeutic antibody, inhibits the interaction between IgE and FcϵRI, preventing mast cell and basophil activation, and blocks IgE binding to CD23 on B cells and antigen-presenting cells. We solved the crystal structure of the complex between an omalizum...

The house dust mite is one of the most common allergens worldwide. There is good evidence that house dust mite subcutaneous immunotherapy is efficacious and has long-term benefit in children. However, the evidence of the benefit of house dust mite sublingual immunotherapy (SLIT) is less convincing. The purpose of this meta-analysis was to evaluate that efficacy and safety of dust mite SLIT in c...

Current Opinion in Allergy and Clinical Immunology 2008, 8:110–114 Purpose of review This review examines the relationship between exposure to workplace allergens and the risk of developing occupational allergy. Recent findings Evidence suggests that the risk of developing occupational allergy increases with allergen exposure; however, with some occupational allergens, this exposure–response re...

BACKGROUND The UK guidelines for the use of anti-D immunoglobulin for rhesus prophylaxis have been revised. Anti-D immunoglobulin is no longer recommended for Rh D negative women after a threatened miscarriage less than 12 weeks gestation. These patients are at risk of rhesus immunisation, and there should be a policy for their treatment in the accident and emergency (A&E) department. DESIGN ...

Immunoglobulin (adsorbed resistance antiserum) reacting specifically with antigens from tetracycline (Tc)-resistant Staphylcoccus aureus or Escherichia coli was produced by adsorbing immunoglobulin against cell envelopes of resistant strains with envelope extracts from the respective isogenic susceptible strains. Adsorbed resistance antiserum against S. aureus reacted with envelope extracts fro...

0892-6638/93/0007-0149/$01.50. © FASEB 149 ABSTRACT We have detected an immunoglobulin heavy-chain trans-mRNA of the e class in which the variable region of the human transgenic t chain is correctly spliced to the first exon of the endogenous mouse #{128} constant region. Together with our previous observations, all the endogenous isotypes that are targets of class switching have proved to be e...

Kimura's disease is a rare inflammatory disorder of unknown cause, primarily seen in young Asian males. The disease is characterized by a triad of painless subcutaneous masses in the head or neck region, blood and tissue eosinophilia, and markedly elevated serum immunoglobulin E levels. We describe an 11-year-old Asian boy with Kimura's disease who presented with a chronic left neck mass. The d...

Job’s syndrome, a subset of the Hyper-immunoglobulin E (IgE) recurrent Infection Syndrome (HIES), is a rare primary immunodeficiency disorder characterized by a classic clinical triad of recurrent staphylococcal abscesses, recurrent cyst-forming pneumonia, and markedly elevated serum IgE level. To date, slightly more than 200 cases have been published worldwide. Here we review HIES and report o...