Background and Objective: This study was undertaken to analyze the immunohistochemical expression of fibroblast growth factor receptor (FGFR3) in urothelial carcinoma and correlate its expression with the pathological stage, recurrence and other clinicopathological parameters. Material and Methods: A retrospective study was undertaken on paraffin blocks o...

Abstract Background Diabetic encephalopathy is a severe diabetes complication with cognitive dysfunction and neuropsychiatric disability. The mechanisms underlying diabetic believed to be relevant oxidative stress, vascular amylin deposition, immune receptors, inflammation, etc. This study wanted evaluate the ability of curcumin its analog A13 alleviate stress inflammation in diabetes-induced d...

Background: Low back pain is often caused by the degeneration of intervertebral disc. Cigarette smoking has been found to be related disturbance disc function. This study aimed evaluate type II collagen expression in after cigarette smoke exposure with an experimental using male wistar rats. Methods: research was post-test only group design conducted January April 2021. The samples were 21 adul...

background: hirschsprung disease is a complex genetic disorder of the enteric nervous system (ens), often called congenital aganglionic megacolon and characterized by the absence of enteric neurons along a variable length of the intestine. the definitive diagnosis of hirschsprung disease relies on histologic and/or histochemical staining of sections from suction rectal biopsies. calretinin immu...

localized leishmania lymphadenitis (l.l.l) is a self limited clinical presentation of cutaneous leishmaniasis. microscopic findings in l.l.l are very similar to toxoplasma lymphasenitis. in all cases, an intensive microscopic search should be done for leishman bodies. in this study, we describe our microscopic findings and results of our immnohistochemical (ihc) study with a panel of monoclonal...

Purified tissue ferritins isolated from Bantu subjects with gross haemosiderosis, from a patient with idiopathic haemochromatosis (HC) treated by phlebotomy, and from rats with experimental iron overload were studied in order to determine the significance of the abnormality previously demonstrated in tissue isoferritins in patients with IHC. The isoferrin profile of the tissues from the Bantu s...

BACKGROUND The recommended screening of rabies in 'suspect' animal cases involves testing fresh brain tissue. The preservation of fresh tissue however can be difficult under field conditions and formalin fixation provides a simple alternative that may allow a confirmatory diagnosis. The occurrence and location of histopathological changes and immunohistochemical (IHC) labelling for rabies in fo...

More detailed examination of the sentinel lymph node (SLN) in breast cancer has raised concerns about the clinical significance of micrometastases, specifically isolated tumor cells detected only through immunohistochemical (IHC) staining. It has been suggested that these cells do not carry the same biologic implications as true metastatic foci and may represent artifact. A retrospective instit...