Duchenne muscular dystrophy (DMD) and Becker muscular dystrophy (BMD) are X-linked recessive disorders caused by mutations of the DMD gene located at Xp21. In DMD patients, dystrophin is virtually absent; whereas BMD patients have 10% to 40% of the normal amount. Deletions in the dystrophin gene represent 65% of mutations in DMD/BMD patients. To explain the contribution of immunohistochemical a...

RATIONALE Schwannomas of gastrointestinal tracts are rare and difficult to detect preoperatively because of negative results of endoscopic and imaging examinations. Here, we reported a case of rectal schwannoma, which was diagnosed by immunohistochemical staining after laparoscopic protectomy. PATIENT CONCERNS A 61-year-old woman complained of a 1-month history of difficulty in defecation and...

objective: to evaluate the potentiality of ovcar–3 cell line of ovarian adenocarcinoma as a xenograft model for ovarian adenocarcinoma in nude mice. materials and methods: the cell line isolated from advanced human ovarian adenocarcinoma, were inoculated to eight nude mice and two months later. established tumors were transferred to pathology laboratory to be prepared by h&e; staining and immun...

Some hepatocellular adenoma (HCA) subtypes are characterized by different CTNNB1 mutations, leading to beta-catenin activation levels, hence variable immunostaining patterns of glutamine synthetase (GS) expression, and risks malignant transformation. In a retrospective multicentric study 63 resected inflammatory (n=33) noninflammatory (n=30) molecularly confirmed CTNNB1-mutated b-(I)HCA, we inv...

Background. Scrub typhus results in vasculitis due to Orientia tsutsugamushi infection. The present study investigated whether O. tsutsugamushi infection is associated with gastric ulcer etiology and whether immunohistochemical staining of stomach tissue is useful to diagnose scrub typhus. Methods. A 78-year-old woman was hospitalized owing to general weakness that begun 4 days prior. As scrub ...

The importance of p53 mutations in the pathogenesis of human lung carcinoma is well established, but it is still controversial whether the presence of p53 mutations or overexpression of p53 protein adversely affects an individual patient's chances of survival. The controversy may be partially due to the methodological differences in examination for p53 alterations: gene analysis or immunohistoc...

OBJECTIVE Can polymer-based immunohistochemical staining of p57(kip2) replace DNA analysis as an inexpensive means of differentiating complete mole from partial mole or hydropic abortion? METHODS AND MATERIALS Original paraffin-embedded tissue blocks from 14 equivocal cases were turned over to our laboratory and examined by immunohistochemical staining of p57(kip2). RESULTS Four of the 14 c...