Acquired chemo-resistance is one of the key causal factors in cancer death. Emerging evidences suggest that miRNA and epithelial-mesenchymal transition play critical roles in the chemo-resistance in cancers. Here, we showed the association of paclitaxel-resistance with miR-375 over-expression and epithelial-mesenchymal transition inducement in cervical cancer. Using different cervical cancer ce...

abstract since for some reasons such as studying the behaviour of old construction materials and proper replacement of the deteriorated sections, adequate knowledge about the true in situ strength of the construction materials has become a necessity, many attempts have been made to invent and develop new in situ methods in recent years. most of these methods measure the in situ strengths of mat...

Bryostatin is a unique lead in the development of potentially transformative therapies for cancer, Alzheimer's disease and the eradication of HIV/AIDS. However, the clinical use of bryostatin has been hampered by its limited supply, difficulties in accessing clinically relevant derivatives, and side effects. Here, we address these problems through the step-economical syntheses of seven members ...

in this study, the recycling possibility of residual oil fly ash (rofa) towards preparing activated carbon and its application in environmental remediation through adsorbing cu (ii) and pb (ii) ions from aqueous solutions were investigated. activated carbons were prepared using two different physical activation methods such as under steam flow at 950 0c, and combined steam and co2 flow at 850 0...

We revealed the processes for activation, mechanically induced self-sustaining reaction (MSR) and crystal growth of Ag in mechanochemical reduction AgCl with Al by situ synchrotron X-ray diffraction.

This study was aimed to evaluate the correlation between in vitro fermentation and in situ degradation parameters and to predict dry matter degradability and energy protein synchronization of roughage based diets. Different inclusion of roughage in diets [roughage 50% diet (R50D), roughage 60% diet (R60D), roughage 65% diet (R65D) and roughage ...

Background and Objective: Since the advent of mammography screening, ductal carcinoma in situ (DCIS) of the breast has been diagnosed increasingly. In contrast to the situation in invasive breast carcinoma, there are only a few reports on androgen receptor (AR) status in DCIS and few reports on estrogen ...

This study presents methods for treating a kind of nanoclay and investigates the effects of methylaluminoxane (MAO) exposure time and or dodecylamine (DDA) reflux time on in-situ polymerization of ethylene in the presence of nanoclay and examines the morphology and properties of the prepared polyethylene/clay nanocomposites. The results revealed that by increasing MAO exposure time productivity...

In situ detection of calpain activation in intact cells has not been possible to date. Here we present the first direct evidence, employing a novel approach, that mu-calpain is rapidly activated at cell membranes in platelets upon a rise in intracellular calcium concentration. Immunoelectron microscopy using antibodies capable of distinguishing between the pre- and postautolysis forms of mu-cal...

Permeabilized germlings from the dimorphic fungus Mucor rouxii were used for in situ measurement of protein kinase A (PKA) activation, to compare the results with those obtained in vitro at low or high (nonlinear) enzyme concentrations. The apparent total activity per cell when measured in situ is 5- to 10-fold lower than the in vitro measured activity in crude extracts from those cells. Polyam...