Background: Determining bipolar disorder in polycystic ovarian syndrome (PCOs) women. Materials and Methods: One hundred and ten women with definite diagnosis of PCOS and one hundred and ten age-matched infertile women due to other reasons except for PCOS enrolled in this case-control study. Ten ml fasting venous blood sample obtained to check of fasting glucose, LH, FSH. Height, weight, Waist-...

The aim of this study was to calculate the relative prevalence of all phenotypes of polycystic ovary syndrome (PCOS) and to compare them for anthropometrical, hormonal and metabolic differences according to the Rotterdam Criteria. A total of 300 women with PCOS aged 26.7 +/- 5.6 years (mean +/- SD) and 100 women aged 28.3 +/- 4.1 years (mean +/- SD) were included in a control group. Anthropomet...

Follistatin plays an important role in female physiology by regulating FSH levels through blocking activin actions. Failure to regulate FSH has been implicated as a potential cause of premature ovarian failure. Premature ovarian failure is characterized by amenorrhea, infertility, and elevated gonadotropin levels in women under the age of 40. Because follistatin is essential for postnatal viabi...

Spontaneous ovarian hyperstimulation syndrome (sOHSS) is a rare event that may result from a FSH-producing pituitary adenoma (FSHoma), activating mutations of the FSH receptor (FSHR), and cross-reactivity of the FSHR to elevated hCG and TSH in the setting of pregnancy or hypothyroidism. The objective of this study was to investigate whether an aberrant FSHR was present in a woman with sOHSS and...

The chromosomal aneuploidies were analyzed even in the sperm extracted from testis with regard to the different conditions determining azoospermia including groups with nonobstructive azoospermia and in severe oligozoospermia with high Follicle Stimulating Hormone (FSH) levels [6]. To the best of our knowledge, reports showing values of sperm aneuploidies in presence of high FSH levels are lack...

Sir, I read with much interest the article by Bosch et al. (2010) published recently in the Human Reproduction. In a retrospective analysis, the authors examined the relationship between serum progesterone (P) level on the day of hCG administration (hCG day) and the probability of ongoing pregnancy, in an unselected population of women undergoing controlled ovarian hyperstimulation (COH) for as...

Cytokines play a critical and multifarious role in follicular maturation. Consequently, they may influence the pregnancy outcome in cycles of assisted reproduction. The aim of this study was to measure the levels of tumor necrosis factor-alpha (TNFalpha), vascular endothelial growth factor (VEGF) and leptin in serum and follicular fluids (FFs) from women undergoing controlled ovarian hyperstimu...

background: polycystic ovary syndrome (pcos) is a disorder in which there are numerous benign cysts that form on ovaries under a thick white covering that is one of the causes of infertility. follistatin is a single chain glycosylated polypeptide that can bind to activin. when follistatin binds to activin it suppresses the role of activin to stimulate the secretion of follicle stimulating hormo...

BACKGROUND The purpose of this study was to assess whether, even within a normal FSH range (< or =10 mU/ml), age-specific FSH levels are predictive of ovarian reserve. METHODS Between January 1998 and December 2001, 535 women, undergoing controlled ovarian stimulation with 225 IU of recombinant (rec) FSH and 75 IU of recLH, were included in this retrospective cohort study. Criteria for enrolm...