Patients with locally advanced gastric or gastroesophageal junction adenocarcinoma (LAGC) usually presents significant loss of weight and appetite affecting their overall performance status. FLOT regimen (5-Fluorouracil, Docetaxel oxaliplatin) has a proven role in perioperative management these cancers, however it its own share toxicities. In this retrospective single centre study we evaluate t...

tone, were reported from human and animal species. They were given the name mammalian lignans, because unlike plant lignans they carry phenolic hydroxy groups only in the meta position of the aromatic ring and they were assumed to play an important role in the prevention of hormone-dependent diseases, such as breast cancer and prostate cancer. The origins of enterodiol and enterolactone were la...

Recognition of peptide Ags by T cells through the TCR can be highly specific. In this report we show the degeneracy of Ag recognition at both MHC and TCR levels. We present evidence that unrelated promiscuous Th cell epitopes from various protein sources exhibit sufficient structural homology, despite minimal structural identity, to elicit cross-reactive proliferative responses at the bulk T ce...

A meta-analysis was performed to evaluate the diagnostic value of miR-378 for detecting human cancers. Systematic electronic searches were conducted in PubMed, Web of Science, Embase, China National Knowledge Infrastructure, and Wanfang from the inception to January 15, 2016. We used the bivariate mixed effects models to estimate the combined sensitivity, specificity, PLRs (positive likelihood ...

There is strong evidence that Asp-378 of the yeast PMA1 ATPase plays an essential role in ATP hydrolysis by forming a covalent beta-aspartyl phosphate reaction intermediate. In this study, Asp-378 was replaced by Asn, Ser, and Glu, and the mutant ATPases were expressed in a temperature-sensitive secretion-deficient strain (sec6-4) that allowed their properties to be examined. Although all three...

Macrophage (MΦ) activation must be tightly controlled to preclude overzealous responses that cause self-damage. MicroRNAs promote classical MΦ activation by blocking antiinflammatory signals and transcription factors but also can prevent excessive TLR signaling. In contrast, the microRNA profile associated with alternatively activated MΦ and their role in regulating wound healing or antihelmint...

Introduction: Martian space probe, Viking landers could not measure Ne isotopic ratios, but only had the concentration of Ne as 2.5 ppm (error +3.5, -1.5) in Martian atmosphere [1]. After that, there have been many efforts to determine Ne isotopic composition of Martian atmosphere, by examining the Martian atmospheric gases trapped in impact glasses of the EET 79001 and other shergottites [2-6]...

We construct a generic extension in which the א2 nd canonical function on א1 exists. Supported by NSF and by a Fulbright grant; and Publ. 378, partially supported by the B.S.F.