The quinoline ring plays an important role in many biological systems. Their chemical Synthesis is flexible, can be easily adapted to prepare new derivatives and rationally devised structures, and hopefully can be a source of useful drugs in future. Anticancer activities have been studied for many quinoline derivatives. It has been known that quinoline derivatives may act as anticancer agents t...

In the title compound, C(16)H(12)FNO(3), the dihedral angle between the benzene ring and the plane of the indole ring system is 71.60 (6)°. In the crystal, mol-ecules stack along the b axis through π-π inter-actions between the adjacent indole-2,3-dione units with a centroid-centroid distance of 3.649 (3) Å. Inter-molecular C-H⋯O=C and C-H⋯π inter-actions further stabilize the structure, formin...

Two independent mol-ecules comprise the asymmetric unit of the title chalcone, C(25)H(17)Cl(2)NO, and while each has an E configuration about the ethyl-ene double bond, they differ in the relative orientations of the carbonyl and ethyl-ene double bonds within the prop-2-en-1-one residues, i.e. anti and syn. For each mol-ecule, the benzene [dihedral angles = 71.04 (9) and 73.34 (12)°] and prop-2...

In the title compound, C18H15N3O3, the dihedral angle between the mean planes of the quinoline and indole ring systems [r.m.s. deviations = 0.189 (2) and 0.027 (2) Å, respectively] is 88.65 (5)°. The cyclo-hexene ring of the quinoline ring system adopts an envelope conformation with the central -CH2- C atom as the flap. In the crystal, mol-ecules are linked by two pairs of N-H⋯O hydrogen bonds,...

The mol-ecule of the title compound, C(18)H(12)N(2)O(4), is situated on a crystallographic centre of symmetry. The mol-ecule has a zigzag structure, with two parallel symmetry-related indoline-2,3-dione fragments linked by an ethyl-ene group at each N atom. In the crystal, the mol-ecules stack in columns along the b axis. There are two such columns in the structure. The mol-ecules within each c...

In the title compound, C20H18ClN3O3, the five- and six-membered heterocycles fused through a spiro C atom are inclined to each other at an angle of 87.4 (1)°. In the tricyclic ring system, the cyclo-hexene ring adopts an envelope conformation with the spiro atom as the flap. In the crystal, two sets of N-H⋯O hydrogen bonds link the mol-ecules into columns containing centrosymmetric R 2 (2)(7) r...

The title compound, C19H17ClN2O5, is an important inter-mediate for the synthesis of the pesticide Indoxacarb [systematic name: (S)-methyl 7-chloro-2-{[(meth-oxy-carbon-yl)[4-(tri-fluoro-meth-oxy)phen-yl]amino]-carbon-yl}-2H,3H,4aH,5H-indeno-[1,2-e][1,3,4]oxadiazine-4a-carboxyl-ate] The C=N double bond has a Z conformation. An intra-molecular N-H⋯O hydrogen bond occurs. In the crystal structure...

In the title mol-ecule, C(29)H(22)ClN(3)S, the quinoline ring system, thio-phene ring and phenyl ring substituents are inclined at angles of 71.70 (7), 59.26 (9) and 81.61 (9)°, respectively, to the 4,5-dihydro-pyrazole ring. In the 4-phenyl-quinoline ring system, the phenyl ring makes a dihedral angle of 62.49 (7)° with mean plane of quinoline ring system. In the crystal structure, mol-ecules ...