Onno W. Akkerman, Richard van Altena, Theo Klinkenberg, Adrienne H. Brouwers, Alphons H.H. Bongaerts, Tjip S. van der Werf and Jan-Willem Alffenaar Dept of Pulmonology and Tuberculosis, University of Groningen, University Medical Center Groningen, Groningen, Dept of Cardiothoracic Surgery, University of Groningen, University Medical Center Groningen, Groningen, Dept of Nuclear Medicine and Mole...

Emerging evidence has shown that cellular energy metabolism is regulated by the AMPK and MLK3-JNK signaling pathways, but the functional link between them remains to be determined. The present study aimed to explore the crosstalk between MLK3 and AMPK. We found that both JNK and AMPK were phosphorylated at their activation sites by TNF-α, Anisomycin, H2O2 and sorbitol. Interestingly, sorbitol s...

Objective .- Determine if the addition of hemoglobin testing improves risk prediction for life insurance applicants. Method .- Hemoglobin results for insurance applicants tested from 1993 to 2007, with vital status determined by Social Security Death Master File follow-up in 2011, were analyzed by age and sex with and without accounting for the contribution of other test results. Results .- Hem...

This paper addresses verification issues in combining knowledge bases or theories from different sources. Tile knowledge may be acquired using direct knowledge acquisition or inductive learning methods. Keeping the consistency of knowledge becomes all important issue when integrating two or more knowledge bases. Several independently consistent knowledge bases may give an inconsistent system wh...

Nuclear calcium (Ca(2+)) regulates a number of important cellular processes, including gene transcription, growth, and apoptosis. However, it is unclear whether Ca(2+) signaling is regulated differently in the nucleus and cytosol. To investigate this possibility, we examined subcellular mechanisms of Ca(2+) release in the HepG2 liver cell line. The type II isoform of the inositol 1,4,5-trisphos...

The increasing popularity of XML Web services motivates us to examine if it is feasible to substitute one vendor service for another when using a Web-based application, assuming that these services are “derived from” a common base. If such substitution were possible, end users could use the same application with a variety of back-end vendor services, and the vendors themselves could compete on ...

Recent evidence supports the placement of ctenophores as the most distant relative to all other animals. This revised animal tree means that either the ancestor of all animals possessed neurons (and that sponges and placozoans apparently lost them) or that ctenophores developed them independently. Differentiating between these possibilities is important not only from a historical perspective, b...

Rewarding improves performance. Is it due to modulations of the output modules of the neural systems or are there mechanisms favoring more generous inputs? Some recent study included V1 in the the circuitry of reward-based modulations, but the effects of reward can easily be confused with effects of attention. Here we address this issue with a psychophysical dual task to control attention while...

Active brown adipose tissue is responsible for non-shivering thermogenesis in mammals which affects energy homeostasis. The molecular mechanisms underlying this activation as well as the formation and activation of brite adipocytes have gained increasing interest in recent years as they might be utilized to regulate systemic metabolism. We show here that the transcriptional regulators SRF and M...