A Lewis acid catalyzed reaction of in situ generated 2H-indol-2-one () with various 2π and other electron-rich substrates has been developed. A variety of electron-rich substrates such as allyl/methallyltrimethylsilane, phenylacetylene, styrenes, acetophenone, and indoles have been used. The methodology provides a straightforward approach for the synthesis of 2-oxindoles with an all-carbon quat...

A new, versatile and direct Pd-mediated method involving intramolecular cyclization of N-(2-iodoaryl)-N-(1-alkyl-1H-indol-2-yl)alkane/arene/heteroarene sulfonamide has been developed leading to a diverse and unique class of indolo[2,3-b]indoles for the potential inhibition of sirtuins.

Abstract Benzo[g][1]benzopyrano[4,3-b]indol-6(13H)-ones (BBPIs) are potent anticancer compounds having unique BBPIs ring system designed on the basis of marine natural product lamellarin D. In this study, we describe an alternative synthesis a 2-demethoxy series BBPIs, employing van Leusen pyrrole and intramolecular Heck reaction as key reactions. Cytotoxicity derivatives against several cancer...

The N'-(1-methyl-1H-indol-3-ylmethyl-idene)hydrazine-carbo-dithio-ate portion of the title mol-ecule, C(18)H(17)N(3)S(2), is nearly planar; this unit and the phenyl ring subtend an angle of 112.9 (2)° at the methyl-ene C atom.

Treatment of 3-hydroxyoxindoles with trichloroacetonitrile (1.3 equiv.) and a catalytic amount of DBU (0.1 equiv.) followed by addition of nucleophiles (1.5 equiv.) and diphenylphosphoric acid (0.2 equiv.) afforded the 3,3-disubstituted oxindoles in good to excellent yields. DFT computations supported the notion that the reaction went through the 1-alkyl-2-oxo-2H-indol-1-ium intermediate.

Ziprasidone Capsules contain a monohydrochloride, monohydrate salt of ziprasidone. Chemically, ziprasidone hydrochloride monohydrate is 5-[2-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]ethyl]-6chloro-1,3-dihydro-2H-indol-2-one, monohydrochloride, monohydrate The empirical formula is C21H21ClN4OS · HCl · H2O and its molecular weight is 467.42. Ziprasidone hydrochloride monohydrate is a white to s...

We report catalytic, enantioselective intramolecular hydroacylation of N-vinylindole-2-carboxaldehydes. These hydroacylation reactions occur in the presence of a readily accessible rhodium catalyst and form chiral, non-racemic 2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-ones in high yields with excellent enantioselectivities.

A highly enantioselective method for the catalytic cis-stilbene oxide opening reaction with indole derivatives was developed. The scope of the reaction was studied with a selection of aromatic meso-epoxides and various indoles, and the desired 2-(indol-3-yl)ethanol derivatives were obtained in good to excellent yields with excellent enantioselectivities (from 96 to >99% ee).

Errors were made during the preparation of this manuscript that deviate from accepted scientific norms. Specifically, (1) one figure is flipped horizontally in the control panel of two figures representing the same experiment (Fig 1E and S1A); (2) the same photograph of a genotype is used in Fig 1O that is presented as a control genotype in Fig 4G of a manuscript published in a different journa...