Frequencies and absolute numbers of peripheral T-cell subsets were monitored closely following acute Plasmodium falciparum malaria in 22 Ghanaian children from an area of hyperendemicity for seasonal malaria transmission. The children presented with cerebral or uncomplicated malaria (CM or UM, respectively) or with severe malarial anemia. For all patients the frequencies and absolute numbers of...

The present study investigated the antioxidant effect of aqueous seed extract of Aframomum sceptrum against oxidative stress induced in Plasmodium berghei infected mice. Adult-albino mice (male), weighing 15-25 g, were inoculated intraperitorically with 0.1 ml parasitized blood suspension. A. sceptrum extract was orally administered at different dosages (250 and 350 mg/kgb.wt), daily to both no...

background: this study aimed at determining the prevalence of malaria and anemia among child­ren in rural community of okada, edo state nigeria, as well as to assess the level of use of insecti­cide treated bed nets and its impact on prevalence of malaria and anemia among study population. methods: thick blood films from 226 children with signs and symptoms of malaria in okada commu­nity were s...

malaria is one the major health problem in nigeria. during pregnancy, it poses serious threat to the survival of both unborn foetus and the mothers. this study determined the effect of adequate malaria knowledge and pregnancy status of women on use of mosquito nets and reported malaria fever morbidity.the data were collected during the malaria indicator survey (mis) from 4632 women. data analys...

Following transmission through a mosquito bite to the mammalian host, Plasmodium parasites first invade and replicate inside hepatocytes before infecting erythrocytes and causing malaria. The mechanisms limiting Plasmodium reinfections in humans living in regions of malaria endemicity have mainly been explored by studying the resistance induced by the blood stage of infection. However, epidemio...

Severe malarial anemia (MA) is the primary manifestation of severe malaria among children in areas of holoendemic Plasmodium falciparum transmission. Although overproduction of inflammatory-derived cytokines are implicated in the immunopathogenesis of severe MA, chemokines such as regulated on activation, normal T-cell expressed and secreted (RANTES, CCL5) are largely unexplored in childhood ma...

It is generally known that malaria may produce signs of impaired liver function. In studies on experimentally induced malaria in this laboratory (1, 2), special efforts were made in an attempt to obtain information on four aspects of the question as to the effects on the liver: (1) The magnitude and character of the impairment as indicated by the several methods customarily used in the study of...

1 to 0.06 gm. of the drug. On the other Young and McLendon (1939) found that aPharsen. failed to eradicate the parasites in any one of 10 cases of induced quartan malaria (P. malaria;), though the symptoms were relieved; the viability of the parasites was not affected. Recently Lowe at the School of Tropical Medicine has been experimenting with arsenicals in the treatment of human malaria, and,...

Malaria is one of the most common causes of febrile illness in travelers. Coinfections with bacterial, viral, and fungal pathogens may not be suspected unless a patient fails to respond to malaria treatment. Using novel immunohistochemical and molecular techniques, Plasmodium falciparum, Clostridium perfringens, and Candida spp. coinfections were confirmed in a German traveler to Haiti. Plasmod...

Pyruvate kinase (PKLR) is a critical erythrocyte enzyme that is required for glycolysis and production of ATP. We have shown that Pklr deficiency in mice reduces the severity (reduced parasitemia, increased survival) of blood stage malaria induced by infection with Plasmodium chabaudi AS. Likewise, studies in human erythrocytes infected ex vivo with P. falciparum show that presence of host PK-d...