نتایج جستجو برای: inflammatory biomarkers of sicam

تعداد نتایج: 21200552  

Journal: :The Journal of nutrition 2004
Esther Lopez-Garcia Matthias B Schulze JoAnn E Manson James B Meigs Christine M Albert Nader Rifai Walter C Willett Frank B Hu

We evaluated the hypothesis that intake of (n-3) fatty acids is inversely associated with biomarkers of inflammation and endothelial activation. We conducted a cross-sectional study of 727 women from the Nurses' Health Study I cohort, aged 43-69 y, apparently healthy at time of a blood draw in 1990. Dietary intake was assessed by a validated FFQ in 1986 and 1990. C-reactive protein (CRP) levels...

2016
Nadine M. P. Daan Maria P. H. Koster Marlieke A. de Wilde Gerdien W. Dalmeijer Annemieke M. V. Evelein Bart C. J. M. Fauser Wilco de Jager

OBJECTIVE To study metabolic/inflammatory biomarker risk profiles in women with PCOS and PCOS offspring. DESIGN Cross-sectional comparison of serum biomarkers. SETTING University Medical Center Utrecht. PATIENTS Hyperandrogenic PCOS women (HA-PCOS, n = 34), normoandrogenic PCOS women (NA-PCOS, n = 34), non-PCOS reference population (n = 32), PCOS offspring (n = 14, age 6-8 years), and a p...

Gholamreza Rahbari Banaeian Nemat Bilan, Sina Pakdel, Sina Raeisi

Background Making decision on asthma as an inflammatory disease is done mostly on the airways function and the patient symptoms which most of them are nonspecific and subjective. Also, the children are not able to express their signs and collaboration in examination of the lungs function. Evaluation of serum level inflammatory biomarkers can be useful in assessment of the response to treatment ...

Journal: :Arteriosclerosis, thrombosis, and vascular biology 2004
Moniek P M de Maat Else Marie Bladbjerg Jacob von Bornemann Hjelmborg Lise Bathum Jørgen Jespersen Kaare Christensen

BACKGROUND Inflammation variables (C-reactive protein [CRP], fibrinogen, and soluble intercellular adhesion molecule-1 [sICAM-1]) have been identified as risk factors for cardiovascular disease. It is still not known how much the regulation of inflammatory risk factors is determined by genetic factors, and the aim of this study was to determine the heritability of these inflammation variables a...

2013
Hidetaka Noma Tatsuya Mimura Maria Tatsugawa Katsunori Shimada

BACKGROUND The association of inflammatory factors and the aqueous flare value with macular edema in central retinal vein occlusion (CRVO) patients remains unclear. We investigated the relations between the aqueous flare value and vitreous levels of vascular endothelial growth factor (VEGF), soluble intercellular adhesion molecule-1 (sICAM-1), and interleukin-6 (IL-6) in patients with CRVO and ...

2015
Daniel Mathias Ronald E. J. Mitchel Mirela Barclay Heather Wyatt Michelle Bugden Nicholas D. Priest Stewart C. Whitman Markus Scholz Guido Hildebrandt Manja Kamprad Annegret Glasow

Epidemiological studies indicate long-term risks of ionizing radiation on the heart, even at moderate doses. In this study, we investigated the inflammatory, thrombotic and fibrotic late responses of the heart after low-dose irradiation (IR) with specific emphasize on the dose rate. Hypercholesterolemic ApoE-deficient mice were sacrificed 3 and 6 months after total body irradiation (TBI) with 0...

Journal: :Human molecular genetics 2010
Maja Barbalic Josée Dupuis Abbas Dehghan Joshua C Bis Ron C Hoogeveen Renate B Schnabel Vijay Nambi Monique Bretler Nicholas L Smith Annette Peters Chen Lu Russell P Tracy Nena Aleksic Jan Heeriga John F Keaney Kenneth Rice Gregory Y H Lip Ramachandran S Vasan Nicole L Glazer Martin G Larson Andre G Uitterlinden Jennifer Yamamoto Peter Durda Talin Haritunians Bruce M Psaty Eric Boerwinkle Albert Hofman Wolfgang Koenig Nancy S Jenny Jacqueline C Witteman Christie Ballantyne Emelia J Benjamin

P-selectin and intercellular adhesion molecule-1 (ICAM-1) participate in inflammatory processes by promoting adhesion of leukocytes to vascular wall endothelium. Their soluble levels have been associated with adverse cardiovascular events. To identify loci affecting soluble levels of P-selectin (sP-selectin) and ICAM-1 (sICAM-1), we performed a genome-wide association study in a sample of 4115 ...

2011
Guillaume Paré Paul M. Ridker Lynda Rose Maja Barbalic Josée Dupuis Abbas Dehghan Joshua C. Bis Emelia J. Benjamin Dov Shiffman Alexander N. Parker Daniel I. Chasman

Soluble ICAM-1 (sICAM-1) is an endothelium-derived inflammatory marker that has been associated with diverse conditions such as myocardial infarction, diabetes, stroke, and malaria. Despite evidence for a heritable component to sICAM-1 levels, few genetic loci have been identified so far. To comprehensively address this issue, we performed a genome-wide association analysis of sICAM-1 concentra...

2013
Andre S. Bowers Harvey L. Reid Andre Greenidge Clive Landis Marvin Reid

OBJECTIVE To determine differences in TNF-α, IL-1β, IL-10, sICAM-1 concentrations, leg hypoxia and whole blood viscosity (WBV) at shear rates of 46 sec(-1) and 230 sec(-1) in persons with homozygous S sickle cell disease (SCD) with and without chronic leg ulceration and in AA genotype controls. DESIGN & METHODS fifty-five age-matched participants were recruited into the study: 31 SS subject...

Journal: :American journal of physiology. Regulatory, integrative and comparative physiology 2014
Christian K Roberts Brian H Chen Sandeep Pruthi Martin L Lee

Whether exogenous testosterone is proatherogenic remains controversial. We assessed the effects of graded doses of testosterone on serum markers of oxidative stress, chemotaxis, adhesion, and inflammation in healthy younger and older men. In a double-blind, randomized trial, 121 eugonadal men (n = 61, 18-35 years of age and n = 60, 60-75 years of age) were randomized to one of five groups to re...

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