As a DNA receptor in the cytoplasm, cyclic GMP-AMP synthase (cGAS) contributes to recognition of abnormal cytoplasm and stimulator interferon genes (STING) signaling pathway. cGAS could mediate expression interferon-related genes, inflammatory-related factors, downstream chemokines, thus initiating immune response. The STING protein is key effector It widely expressed across cell types such as ...

The aim of the study was to investigate whether negative effects dietary glycinin are linked structural integrity damage, apoptosis promotion and microbiota alteration in intestine orange-spotted grouper (Epinephelus coioides). basal diet (FM diet) formulated contain 48% protein 11% lipid. Fish meal replaced by soybean (SBM) FM diets prepare SBM diet. Two experimental were prepared, containing ...

GCSs exert their anti-inflammatory effects through influencing multiple signal transduction pathways. Their most important action is switching off multiple activated inflammatory genes through inhibition of HAT and recruitment of HDAC2 activity to the inflammatory gene transcriptional complex. In addition, GCSs may activate several anti-inflammatory genes and increase the degradation of mRNA en...

To evaluate the anti-inflammatory function and underlying genes targeted by bilberry, gene expression profiling through DNA microarray was performed on bilberry extract-treated macrophages. Among 22,050 oligonucleotides, the expression levels of 998 genes were increased by > or = twofold in lipopolysaccharide (LPS)-activated RAW264 cells, 358 gene signals of which were attenuated by bilberry ex...

A cytotoxic enterotoxin (Act) of Aeromonas hydrophila possesses several biological activities, and it induces an inflammatory response in the host. In this study, we used microarrays to gain a global and molecular view of the cellular transcriptional responses to Act and to identify important genes up-regulated by this toxin. Total RNA was isolated at 0, 2, and 12 h from Act-treated macrophages...

Red djulis (Chenopodium formosanum) is a native grain plant, and shows that it has anti-oxidant anti-inflammatory effects. However, was still unclear whether unhulled red extracts promoted collagen production anti-aging. This study aimed to explore the had anti-aging properties. Using treat human fibroblasts for functional analysis, used HPLC analyze effective components of djulis. found can in...

The aim of this study was to perform a genome-wide expression analysis whole-blood samples from people with optic neuritis (ON) and determine differentially expressed mRNAs compared healthy control subjects. included eight acute ON six Gene analyzed using DNA microarrays for whole-human-genome analysis, which contain 54,675 25-base pairs. additional biostatistical gene ontology set enrichment (...

The transcriptional activation of keratinocytes has essential roles for the specific types immune response skin. However, necessary and sufficient conditions in development psoriasis have never been identified. We previously demonstrated that mice lacking TRAF6 specifically are resistant to psoriatic inflammation induced by imiquimod. In addition, we found daily topical treatment with anisomyci...

Mesenchymal stem cells (MSCs) are well known due to their immunomodulatory effect, but the exact mechanisms have not been defined. Several studies demonstrated that the exerted immunoregulatory effect of these cells could be mediated by paracrine factors to illustrate, cytokines, chemokine, and among which, extracellular vesicles are one of them to play a crucial role. Moreover, it is assumed t...