Epidermal nevi are congenital hamartomas of embryonal ectodermal origin classified on the basis of their main component. The compone keratinocytic. An estimated 1/3 of individuals with epidermal nevi have involvement of other organ systems; hence this condition is considered to be epidermal nevus syndrome. Solomon defined epidermal nevus syndrome as a sporadic neuro in the skin, brain, eyes and...

Porokeratoses are uncommon hereditary or acquired keratinization disorders due to abnormal clones of keratinocytes in the epidermis. Porokeratoses have several clinical features which may occur simultaneously. A rare type is verrucous porokeratosis (VPK). Herein, we present a 47-year-old man with a 4-year history of perianal verrucous lesions and one year history of annular pruritic lesions on ...

Corresponding author: Wei-Ming Wu, Department of Dermatology, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Ta-Pei Road 123, Niao-Sung Hsiang, 83301 Kaohsiung, Taiwan TEL: 886-7-7317123 ext. 2299 FAX: 886-7-7337612 E-mail: [email protected] Funding source: none Confl ict of interest: none declared CASE REPORT A 24-year-old girl presented with linear verrucous skin lesions sinc...

A one year-old girl was referred to our dermatology department for assessment of an asymptomatic congenital pigmented lesion on the right posterior flank. Medical history was unremarkable. Dermatologic examination revealed a 30×10 mm homogeneous dark brown plaque with a verrucous surface, which was diagnosed as medium-sized CMN. After seven years of follow-up, the nevus had enlarged proportiona...

The epidermal nevus syndrome (ENS) is an uncommon neurocutaneous disorder in which epidermal nevi are found in association with congenital abnormalities of the brain, eye, and/or skeleton. The association of epidermal nevi and neurologic abnormalities was comprehensively described by Schimmelpenning in 1957. Pavone et al. (1991) identified a homogeneous variant of ENS with hemimegalencephaly, g...

To the Editor: Nevus sebaceous (NS) is an epidermal nevus that is comprised predominantly of sebaceous glands in approximately 0.3% of newborns.[1] Clinically, it presents as a single or, less commonly, multiple yellowish‐colored plaques with overlying alopecia, usually confined on the scalp; however, it can also appear on the face, preauricular area, and neck region.[2,3] Here, we reported a c...

Verrucous epidermal nevi are congenital hamartomas composed of keratinocytes and may occur alone or in association with developmental abnormalities. A close relationship between variations in the PIK3CA and FGFR3 genes and the appearance of nevi has been recently reported. Based on that, we performed molecular assays for the identification of E542K, E545G/K and H1047R mutations in the PIK3CA ge...

Nevus sebaceus is a hamartoma of the sebaceous gland that occurs congenitally, from which various secondary tumors can arise with a prevalence of 5%-6%. Benign neoplasms commonly arise from nevus sebaceous, but they have a very low malignant potential. Two neoplasms may occasionally arise within the same lesion, but it is rare for three or more neoplasms to occur in a nevus sebaceus simultaneou...

Linear lichen planus (LP) is a rare dermatologic disease in which lichenoid lesions conform to a blaschkolinear distribution, most commonly on the extremities. Linear discoid lupus erythematosus (DLE) is a cutaneous manifestation of lupus that also conforms to Blaschko’s lines. Blaschkolinear disorders have been shown to result from somatic mosaicism, most recently in nevus sebaceus, epidermal ...