background and aims. biocompatibility of root-end filling materials is a matter of debate. the aim of this study was to compare the biocompatibility of a variety of commercial proroot wmta cements and a resin-based cement (geristore®) with different ph values of setting reaction and different aluminum contents, implanted into the subcutaneous connective tissue of rats at various time intervals....

the leukotrienes and prostaglandins are biologically active metabolites derived from arachidonic acid. the leukotrienes have a role in inflammatory diseases such as allergic rhinitis, inflammatory bowel disease and asthma. montelukast, a cysteinyl leukotriene receptor antagonist, is claimed to be effective in asthma. the present study aimed to assess the role of cysteinyl leukotriene receptor a...

background periapical lesions are induced in response to injuries to periapical tissues, which are generally the result of infections within the root canal. mast cells actively participate to the inflammatory infiltration of periapical granulomas and cysts. objectives the aim of this study was to detect and compare the presence of mast cells in inflammatory periapical lesions, including cysts a...

introduction: immune system is involved in the etiology and pathophysiology of inflammation and vitamins are important sources of substances inducing nonspecific immunomodulatory effects. given the proinflammatory role of cytokines in the inflammation and pain induction, this study aimed to assess the effects of long-term administration of vitamin b1 on the proinflammatory cytokines, edema, and...

Overwhelming evidences supports the idea that inflammatory bowel disease (IBD) is caused by a complex interplay between genetic alterations of multiple genes and an aberrant interaction with environmental factors. There is growing evidence that epigenetic factors can play a significant part in the pathogenesis of IBD. Significant effort has been invested in uncovering genetic and epigenetic fac...

OBJECTIVE Famotidine given at a dose of 80 mg/day is effective in preventing NSAID-induced gastropathy. The aim of this proof of concept study was to compare twice a day (BID) vs 3-times a day (TID) administration of this total dose of famotidine on intragastric pH in healthy volunteers. RESEARCH DESIGN AND METHODS Two analyses were undertaken: (1) a 13 subject controlled cross-over 24-h intr...

Psoriasis is a complex chronic inflammatory cutaneous disorder. To date, robust molecular mechanisms of psoriasis have been reported. Among diverse aberrant immunopathogenetic mechanisms, the current model emphasizes the role of Th1 and the IL-23/Th17 axis, skin-resident immune cells and major signal transduction pathways involved in psoriasis. The multiple genetic risk loci for psoriasis have ...

Because the patents for biopharmaceutical monoclonal antibodies have or soon will expire, biosimilars are coming to the market. This will most likely lead to decreased drug costs and so easier access to these expensive agents. Extrapolation, however, of the limited available clinical data from adults with rheumatologic diseases to children with inflammatory bowel disease (IBD) should be done wi...

Genome-wide association studies (GWASs) for many complex diseases, including inflammatory bowel disease (IBD), produced hundreds of disease-associated loci-the majority of which are noncoding. The number of GWAS loci is increasing very rapidly, but the process of translating single nucleotide polymorphisms (SNPs) from these loci to genomic medicine is lagging. In this study, we investigated 4,7...