A great deal of new information has arisen in the recent years concerning inhibin physiology and clinical relevance in reproductive medicine. It is now recognized that the two inhibin isoforms, named inhibin A and inhibin B, are produced by the gonads in the course of gamete maturation and in women have a different pattern of secretion throughout the menstrual cycle. Since inhibins are also pro...

Inhibins are endogenous antagonists of activin signaling, long recognized as important regulators of gonadal function and pituitary FSH release. Inhibin, in concert with its co-receptor, betaglycan, can compete with activin for binding to type II activin receptors and, thus, prevent activin signaling. Because bone morphogenetic proteins (BMPs) also utilize type II activin receptors, we hypothes...

Research endocrinologists are well aware of inhibin and the family of proteins of which it is a part. Inhibin was discovered almost 70 years ago as a product of the gonads that selectively inhibited the secretion of folliclestimulating hormone (FSH) at the level of the pituitary gland. We now know that inhibin is present in at least two biologically active forms (inhibin A and B) as well as in ...

تابر مواقم لرتنك هلاقم نيا رد ينيعمان و يجراخ تاشاشتغا دوجو اب رايس ياه متسيس يرتماراپ ياه كيمونولوهريغ يكيتامنيس ديق هك يكيمانيد ١ ار شزغل مدع هدروآرب يمن تسا هتفرگ رارق يسررب دروم ،دننك . هدش زكرمتم يكيتامنيس لرتنك يحارط يور رب هك يلبق ياهراك فلاخرب ساسا رب رواتشگ مواقم رلرتنك كي ،دنا هب ،ميظنت لباق ناسون سناكرف اب اريم كيمانيد رگناسون هناگي شور كي تروص ٢ يبايدر هلأسم ود ره يارب ابر يزا...

ةصلاخلا : برتلا تارفيش تذوحتسا دقل و ً ارخؤ م ب سب نيثحا بلا نم ر يثكلا ما متها ى لع ب أ هابلا ا هئاد ـ د نع ر ـ ل ةضفخنملا مي قلا ) SNR .( اًءز ج ر ثعبملا ر بتعيو اً ماه شلا هذ ه ميمصت ن م في تار . م ظعم ضرتفتو لأا ،ةيئاوشع تار ثعبم لاجملا اذه يف ثاحب أ سرد نف ثحبلا اذ ه يف ا م أ مادختساب و برت تارفي ش ءاد ّ يفص تارثعبم ،ة و ب ةقلعتملا لماوعلا نم ديدعلا أ د اهئا ميمصت لثم ، أ لوط ريثأ تو ،ةيفصلا...

Inhibin, a member of the TGF-beta superfamily, has been proposed to act as an inhibitor of activin and bone morphogenetic protein (BMP) by sequestering their type II receptors in nonsignaling complexes with betaglycan. This mechanism of inhibin action was tested in a mouse adrenocortical (AC) cell line by examining the effects of inhibins A and B on cytochrome P450 17alpha-hydroxylase 17,20-lya...

This study investigates the effects of spermatogenic germ cells on inhibin -subunit and B-subunit expression, and inhibin -subunit and inhibin B production by rat Sertoli cells in vitro. Sertoli cells isolated from 19-day-old rats were cultured for 48 h at 32 C, in the presence or absence of FSH (2·3–2350 mIU/ml), and in the presence of pachytene spermatocytes, round spermatids or cytoplasts of...

Malignant ovarian epithelial tumors have been shown to have decreased inhibin production relative to activin production compared with normal ovarian surface epithelial (OSE) cells and nonmalignant ovarian tumors. Activin stimulates proliferation of many ovarian cancer cell lines. Inhibin antagonizes the action of activin, and inhibin-deficient mice develop gonadal tumors, suggesting that inhibi...

We have analyzed the results of the latest terrestrial neutrino oscillation experiments in the framework of a model with mixing of three massive neutrinos and a neutrino mass hierarchy (m1 ≪ m2 ≪ m3). In this model, oscillations of the terrestrial neutrinos are characterized by three parameters, ∆m2 ≡ m3 − m1 and the squared moduli of the two mixing matrix elements Ue3 and Uμ3. Using the result...

In a previous study (see Ref.7), the molecular weight distribution of inhibin activity in fractionated human follicular fluid (hFF) and human male and female plasma/serum was determined by in vitro bioassay using ovine pituitary cells in culture and various specific inhibin A and inhibin alpha-subunit-directed immunoassays. It was shown, however, that the ovine in vitro bioassay detected inhibi...