herbal medicinal products have attracted significant research interest in recent years. considering the efficiency of algae products in controlling pathogenic bacteria and also easy access to large resources of algae, this study was conducted to evaluate the effects of methanolic, chloroformic and aqueous extracts of gracilaria salicornia against aeromonas hydrophila , a heterotrophic, gram-neg...

in addition to its antioxidant effect, vitamin e or α–tocopherol is suggested to enhance remyelination in the animal model of non-inflammatory demyelination. in this study, the possible proliferative effect of vitamin e on human- induced pluripotent stem cell-derived neural progenitors (hips-nps) and the underlying mechanisms were investigated in vitro. nps were induced from ips cells via 3 ste...

objectives the current research aimed to study achillea millefolium and thymus vulgaris antiviral activity against newcastle disease virus (ndv). materials and methods the antiviral activity of the plants was measured by the reduction assay of viral titer, and explained by inhibition percentage (ip). background nowadays natural products such as pure compounds and plant extract scan provide unli...

artemisinin and its derivatives are very important new class of antimalarial drugs. one of the most important artemisinin derivatives is artemether. the antiparasitic activity of artemether as a derivative of artemisinin is related to endoperoxide bridge in its structure. the aim of this study was the evaluation of antileishmanial effect of artemether, with more focus on its apoptotic effect. i...

Immunogenicity assessments in response to drug treatment are commonly performed using a tiered approach strategy. All samples are initially tested in a screening assay followed by the evaluation of the screened positive samples in a confirmatory assay. Percent inhibition of signal intensity by the competing unlabeled drug in a confirmatory assay is typically used to measure the specificity of a...

The cytotoxic activity of ethanolic extracts of Thymus vulgaris, Thuja orientalis and Achillea millefolium was investigated on various growing tumor cell lines. MTT colorimetric assay was used for measuring the inhibition of cell proliferation. All of the three extracts showed a relatively dose-dependent inhibition of proliferation of human breast cancer (SK-Br-3, MDA-MB-435) and leukemia ...

Inhibition of the mammalian soluble epoxide hydrolase (sEH) is a promising new therapy in the treatment of disorders resulting from hypertension and vascular inflammation. A spectrophotometric assay (4-nitrophenyl-trans-2,3-epoxy-3-phenylpropyl carbonate, NEPC) is currently used to screen libraries of chemicals; however this assay lacks the required sensitivity to differentiate the most potent ...

Diabetes Mellitus (DM) is a major metabolic disorder causing morbidity and mortality worldwide. The prominent adverse effects of allopathic drugs are the principal reason for an escalating number people seeking alternative complementary-based therapies that may have less or no effects. poly-herbal formulation Vilva Kudineer Choornam (VKC) combination Siddha medicinal plants treatment diabetes. ...

This study will examine the effect of a series of metals on the luciferase activity expression induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin (2,3,7,8-TCDD) in H1L6.1 cells. A 2-level factorial design was employed to identify major influential metal species of four test metals (As(5+), Cr(6+), Cd(2+), and Pb(2+)) in the chemically activated luciferase expression (CALUX) of H1L6.1 cells. The obs...

The antioxidant, antimicrobial and anticancer activity of n-hexane extract Mollugo nudicaulis Lam. is interest. antioxidant the was determined by separate methods radical scavenging assays. Antimicrobial analyzed disc diffusion method on fungi species, gram positive negative species. potential plant evaluated A2780 cell lines MTT assay. Results exposed that, M.nudicaulis possess comparable sign...