An educational physical education (PE) hybridization program based on the personal and social responsibility model gamification strategies was used in order to explore effect cognitive performance academic achievement. A 9-month group-randomized controlled trial conducted, with 150 participants (age: 14.63 ± 1.38) allocated into control group (CG, n = 37) experimental (EG, 113). Inhibition, ver...

Morphine was used as a remedy for the control of diarrhea centuries before it's sedative-analgesic effect was discovered. Although several mechanisms have been proposed for the morphine-induced inhibition of gastrointestinal transit (OIT), the exact mechanism has not yet been identified. On this basis the possible involvement of the dopaminergic system in morphine-induced inhibition of tra...

cyclooxygenase-2 (cox-2) has a pivotal role in the pathogenesis of the lung cancer. it is known that cox-2 negatively regulates the activity of a number of tumor suppressors, including p53. consequently, inhibition of cox-2 signaling is anticipated to be a promising approach to stabilize p53 functionality. in this regard, we investigated the effect of cox-2 signaling blockade on p53 and cox-2 e...